Compositions and methods for binding lysophosphatidic acid

An isolated antibody, or antigen-binding fragment thereof, that binds lysophosphatidic acid (LPA) under physiological conditions, wherein the antibody or antigen-binding fragment thereof comprises two immunoglobulin heavy chain variable domains and two immunoglobulin light chain variable domains, wherein:

• a. each immunoglobulin heavy chain variable domain comprises first, second, and third heavy chain complementarity determining regions (CDRs), wherein the first heavy chain CDR comprises an amino acid sequence selected from the group consisting of SEQ ID NO:
• 56, 68, and 91, the second heavy chain CDR comprises an amino acid sequence selected from the group consisting of SEQ ID NO:
• 57, 69, 79, and 92, and the third heavy chain CDR comprises an amino acid sequence selected from the group consisting of SEQ ID NO:
• 58, 70, 80, 84, and 93;
• and,
• b. each immunoglobulin light chain variable domain comprises first, second, and third light chain CDRs, wherein the first light chain CDR comprises an amino acid sequence selected from the group consisting of SEQ ID NO:
• 59, 71, 81, and 94, the second light chain CDR comprises an amino acid sequence selected from the group consisting of SEQ ID NO;
• 60, 72, 82, and 95, and the third light chain CDR comprises an amino acid sequence selected from the group consisting of SEQ ID NO:
• 61 and 96.