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US 8,158,109 B2Granted
Foamable suspension gel
AssigneeStiefel Research Australia Pty Ltd
InventorsAlbert Zorko Abram, Lilian Fuchshuber
Life of this patent
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Abstract
The present subject matter provides foamable suspension gels that foam after release from a container. The foamable suspension gels contain at least one pharmaceutically active agent that is sparingly soluble to insoluble in water, a second pharmaceutically active agent, and optionally a third active agent.
Claims37
An aqueous foamable suspension gel in a pressurized container, comprising:
- an aqueous phase comprising water;
- from about 1% to about 25% by weight based on the total weight of the gel of benzoyl peroxide as the sole active agent present having an average diameter of about 10 to about 100 μm suspended in the aqueous phase;
- a thickening agent in an amount sufficient to result in the foamable suspension gel having a viscosity of about 5,000 to about 15,000 cP at 25° C.;
- and
- an aerosol propellant;
- wherein the foamable suspension gel comprises at least 30% by weight based on the total weight of the gel of water and is alcohol-free and oil-free, and
- wherein the foamable suspension gel forms a homogenous foam when dispensed from the pressurized container.
4 more elements
An aqueous foamable suspension gel in a pressurized container, comprising:
- an aqueous phase comprising water;
- from about 1% to about 25% by weight based on the total weight of the gel of benzoyl peroxide as the sole active agent present having an average diameter of about 10 to about 100 μm suspended in the aqueous phase;
- a thickening agent in an amount sufficient to result in the foamable suspension gel having a viscosity of about 5,000 to about 15,000 cP at 25° C.;
- a wetting agent;
- an aerosol propellant;
- and
- wherein the foamable suspension gel comprises at least 70% by weight based on the total weight of the gel of water and is alcohol-free and oil-free, and forms a homogenous foam when dispensed from the pressurized container.
4 more elements
An aqueous foamable suspension gel in a pressurized container, comprising:
- an aqueous phase comprising water;
- from about 2% to about 8% by weight based on the total weight of the gel of benzoyl peroxide as the sole active agent present having an average diameter of about 10 to about 100 μm suspended in the aqueous phase;
- a thickening agent in an amount sufficient to result in the foamable suspension gel having a viscosity of about 5,000 to about 15,000 cP at 25° C.;
- a wetting agent;
- an aerosol propellant;
- and
- wherein the foamable suspension gel comprises at least 70% by weight based on the total weight of the gel of water and is alcohol-free and oil-free, and forms a homogenous foam when dispensed from the pressurized container.
4 more elements
Dependencies are inferred from the claim text.