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US 8,157,999 B2Granted
Method and apparatus for the filtration of biological solutions
AssigneeSpf Innovations, LLC
InventorsGaston de los Reyes, Leon Mir
Life of this patent
Estimating the term…
Abstract
A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.
Claims12
A single-pass tangential-flow filtration system comprising:
- a plurality of substantially identical stages, each stage having a plurality of channels;
- each of the channels has a length, a membrane area, a void volume, a specific membrane area σC expressed as a ratio of the membrane area to the void volume, and a dimensionless length λ expressed as a product of the channel length and the specific membrane area;
- and
- a dimensionless length of the system is greater than about 2,000;
- a dimensionless length of at least one of the plurality of substantially identical stages is less than about 6,000 to provide relatively short flow paths for individual stages;
- and
- wherein each of the substantially identical stages comprises a cassette.
4 more elements
A single-pass tangential-flow filtration system comprising:
- a plurality of substantially identical stages, each stage having a plurality of channels;
- each of the channels has a length, a membrane area, a void volume, a specific membrane area σC expressed as a ratio of the membrane area to the void volume, and a dimensionless length λ expressed as a product of the channel length and the specific membrane area;
- and
- a dimensionless length of the system is greater than about 2,000;
- a dimensionless length of at least one of the plurality of substantially identical stages is less than about 6,000 to provide relatively short flow paths for individual stages;
- wherein the dimensionless length of each of the plurality of substantially identical stages is substantially identical;
- and
- wherein a specific membrane area of a channel in one of a plurality of substantially identical stages, is greater than about 40 cm−1.
5 more elements
Dependencies are inferred from the claim text.