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US 8,153,843 B2Granted
Antibacterial agents
AssigneesUniversity of Washington, Novartis Vaccines and Diagnostics, Inc.
InventorsNiels H. Andersen, Jason Bowman, Alice L. Erwin, Eric A. Harwood, Toni Kline, Khisimuzi E. Mdluli, Simon Ng, Keith B. Pfister, Ribhi Shawar, Allan S. Wagman, Asha Yabannavar
Life of this patent
Estimating the term…
Abstract
Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
Claims17
A compound according to the formula IA:
- or a stereoisomer, pharmaceutically acceptable salt, or ester thereof, wherein
- D is selected from the group consisting of
- (1) substituted or unsubstituted C3-C8-cycloalkyl,
- (2) substituted or unsubstituted aryl, and
- (3) substituted or unsubstituted heterocyclyl;
- Y is selected from the group consisting of
- (1) substituted or unsubstituted C3-C8-cycloalkyl,
- (2) substituted or unsubstituted aryl,
- (3) substituted or unsubstituted heterocyclyl, and
- (4) substituted or unsubstituted heteroaryl;
- R4 is H or substituted or unsubstituted C1-C6-alkyl;
- and
- A is —C(R1a,R2a)OR3a,
- wherein R1a, R2a, and R3a are independently selected from the group consisting of
- (1) H and
- (2) substituted or unsubstituted C1-C6-alkyl;
- with the proviso that at least one of R1a, R2a, and R3a is a substituted or unsubstituted C1-C6-alkyl.
14 more elements
A compound according to the formula IB:
- or a stereoisomer, pharmaceutically acceptable salt, or ester thereof, wherein
- D is absent or selected from the group consisting of
- (1) substituted or unsubstituted C3-C8-cycloalkyl,
- (2) substituted or unsubstituted aryl, and
- (3) substituted or unsubstituted heterocyclyl;
- G is —C≡C—C≡C—;
- Y is selected from the group consisting of
- (1) substituted or unsubstituted C3-C8-cycloalkyl,
- (2) substituted or unsubstituted aryl,
- (3) substituted or unsubstituted heterocyclyl, and
- (4) substituted or unsubstituted heteroaryl;
- R4 is H or substituted or unsubstituted C1-C6-alkyl;
- and
- A is —C(R1a, R2a)N(R4a, R5a), wherein R1a, R2a, R4a, and R5a are independently selected from the group consisting of
- (1) H and
- (2) substituted or unsubstituted C1-C6-alkyl.
13 more elements
Dependencies are inferred from the claim text.