US 8,153,689 B2Granted

Pleuromutilin derivatives for the treatment of diseases mediated by microbes

AssigneeNabriva Therapeutics AG

InventorsRosemarie Mang, Werner Heilmayer, Rudolf Badegruber, Dirk B. Strickmann, Rodger Novak, Mathias Ferencic, Atchyuta Rama Chandra Murty Bulusu

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Abstract

Disclosed are pleuromutilin derivatives of formula (I) and their use in the treatment of diseases mediated by microbes.

Claims5

Dependent claims

A composition comprising the compound 14-O-{[(1R, 2R, 4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin, wherein said compound has the structure of formula (I):

Dependencies are inferred from the claim text.

Facts

Application: 13/252,732Filed 4 Oct 2011 · continuation
Priority: EP 0745005320 Mar 2007
Published: US 2012/0029072 A12 Feb 2012
Granted: 10 Apr 2012
Term ends: Not estimatedThe source records don’t support an estimate.

Classification17 codes

A61K 31/5375
Having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines: 1,4-Oxazines, e.g. morpholine
A61K 31/215
Esters, e.g. nitroglycerine, selenocyanates: of carboxylic acids
A61K 31/357
Having oxygen as the only ring hetero atom, e.g. fungichromin: having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
A61P 17/10
Drugs for dermatological disorders: anti-acne agents

Family

PCT/AT2008/000097Parent of this continuation · filed 19 Mar 2008
US 2012/0029072 A1Pre-grant publication · published 2 Feb 2012
Application12/531,839Parent of this continuation
US 8,071,643 B2Parent of this continuation
US 2010/0035987 A1Published application
US 8,153,689 B2This patent

From the US filing history. Foreign family members aren’t listed.

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