# US 8,150,495 B2 · Bodily sealants and methods and apparatus for image-guided delivery of same > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,150,495 B2 - Document ID: US8150495B2 - Status: Granted - Kind: B2 - Application number: 12/267,200 - Filed: 2008-11-07 - Published: 2009-11-12 - Granted: 2012-04-03 - Earliest claimed: 2003-08-11 - Assignees: Veran Medical Technologies, Inc. - Inventors: Jerome R. Edwards; Christopher B. Lee; Troy L. Holsing; Torsten M. Lyon - Web page: https://patentgrep.com/patent/US8150495B2 ## CPC - A61B 17/00491: {Surgical glue applicators} - A61B 5/062: {using magnetic field} - A61B 6/541: {involving acquisition triggered by a physiological signal} - A61B 34/20: Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis - A61B 90/36: {Image-producing devices or illumination devices not otherwise provided for} - A61B 5/352: Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval - A61B 5/7285: {for synchronizing or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal} - A61B 6/12: Arrangements for detecting or locating foreign bodies - A61B 8/0833: {involving detecting or locating foreign bodies or organic structures} - A61B 34/10: Computer-aided planning, simulation or modelling of surgical operations - A61B 2017/00703: {correcting for movement of heart, e.g. ECG-triggered} - A61B 2034/2051: {Electromagnetic tracking systems} - A61B 2034/2072: {Reference field transducer attached to an instrument or patient} - A61B 2090/3916: {Bone tissue} - A61B 2090/3954: {magnetic, e.g. NMR or MRI} - A61B 2090/3958: {emitting a signal} - A61B 2090/3983: {Reference marker arrangements for use with image guided surgery} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract Generally, systems, methods, and apparatus related to the use of a dynamic imaging modality in an image guided intervention are disclosed herein. More specifically, the use of such modalities in sealing a bodily opening, such as those that may be formed during an invasive medical procedure are disclosed herein. In some embodiments, a method includes viewing a representation of an instrument within a body of a patient, adjusting a position of the instrument based on the viewing such that a portion of the instrument is at a location within the body of the patient, and delivering a sealant via the instrument to the location within the body of the patient. The sealant is configured to seal an opening in the body part. ## Claims ### Claim 1 A method, comprising: viewing a representation of an instrument within a body of a patient, the representation being superimposed on an image of a plurality of images associated with a cyclical movement of a body part, the image being associated with a match dataset vector (MDV), the MDV being a dataset vector most similar to a current vector that is calculated based on a current position of a first reference marker and a current position of a second reference marker, the second reference marker being depicted in at least one image of the plurality of images; adjusting a position of the instrument based on the viewing such that a portion of the instrument is at a location within the body of the patient; and delivering a sealant via the instrument to the location within the body of the patient, the sealant being configured to seal an opening in the body part. ### Claim 2 (depends on 1) The method of claim 1, wherein the viewing includes detecting a representation of a third reference marker, the third reference marker being disposed on the instrument. ### Claim 3 (depends on 1) The method of claim 1, further comprising: generating the plurality of images using at least one of fluoroscopy, computed tomography, magnetic resonance imaging, positron emission tomography, ultrasound, or optical coherence tomography. ### Claim 4 (depends on 1) The method of claim 1, further comprising: generating the plurality of images using at least one of a 2-dimensional, 3-dimensional, or 4-dimensional imaging device. ### Claim 5 (depends on 1) The method of claim 1, further comprising: detecting a first pressure within a portion of the body of the patient proximate to the instrument at a first time; and detecting a second pressure within a portion of the body of the patient proximate to the instrument at a second time later than the first time, the second pressure being at least a threshold value, the delivering performed when the second pressure is detected. ### Claim 6 (depends on 1) The method of claim 1, wherein the adjusting includes moving the instrument from a first position to a second position different than the first position, further comprising: detecting a first pressure within a portion of the body of the patient proximate to the instrument at its first position; and detecting a second pressure within a portion of the body of the patient proximate to the instrument at its second position different than the first position, the second pressure being at least a threshold value, the delivering performed when the second pressure is detected. ### Claim 7 (depends on 1) The method of claim 1, wherein the delivering includes disposing at least a portion of the sealant on an interior surface of the body part. ### Claim 8 (depends on 1) The method of claim 1, wherein the delivering includes: exposing a coating disposed on an outer surface of a portion of the instrument to a bodily fluid, the coating including the sealant, at least one of the coating or the sealant having a first physical state prior to the exposing and a second physical state different than the first physical state after the exposing; and placing the coating in contact with the body part having cyclical movement. ### Claim 9 (depends on 1) The method of claim 1, wherein the delivering includes releasing a seal member from the instrument to the body part having cyclical movement, the seal member includes a substrate, the sealant disposed on a portion of the substrate. ### Claim 10 (depends on 1) The method of claim 1, wherein the delivering includes moving a seal member from a first configuration to a second configuration, the seal member being collapsed and at least partially disposed within a portion of the instrument when the seal member is in its first configuration, the seal member being expanded and at least partially disposed outside of the portion of the instrument when the seal member is in its second configuration. ### Claim 11 (depends on 1) The method of claim 1, wherein the delivering includes moving a protrusion of a delivery mechanism of the instrument from a first position to a second position, the protrusion being extended from the delivery mechanism at a first angle when the protrusion is in its first position, the protrusion being extended from the delivery mechanism at a second angle when the protrusion is in its second position, the second angle greater than the first angle. ### Claim 12 (depends on 1) The method of claim 1, wherein the delivering includes moving a first shaft of the instrument with respect to a second shaft of the instrument to place an opening defined by the first shaft in fluid communication with an opening defined by the second shaft. ### Claim 13 (depends on 1) The method of claim 1, wherein the sealant is configured to form a seal between a portion of the instrument and the body part defining the opening. ### Claim 14 (depends on 1) The method of claim 1, wherein the sealant includes at least one of thrombin, fibrinogen, a cyanocrylate, collagen, a cross-linker, an aldehyde, or a hydrogel.