Method of producing tibolone metabolites by fermentation with Gibberella fujikuroi
OwnerAttaur Rahman, Muhammed Iqbal Choudhary +2inventors
InventorsAttaur Rahman, Muhammed Iqbal Choudhary, Syed Adnan Ali Shah, Shamsun Nahar Khan
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Abstract
Method of producing Δ5-Tibolone (C21H28O2), 6β-Hydroxy-Δ4-tibolone (C21H28O3), 6α-Hydroxy-Δ4-tibolone (C21H28O3), 15α-Hydroxy-Δ4-tibolone (C21H28O3), 6α-Hydroxy-Δ1,4-tibolone (C21H28O3) and 6β-Methoxy-Δ4-tibolone (C22H30O3) contacting tibolone with Gibberella fujikuroi (ATCC 10704) is reported.
Claims1
A microbial method of producing Δ5-Tibolone (C21H28O2), 6β-Hydroxy-Δ4-tibolone (C21H28O3), 6α-Hydroxy-Δ4-tibolone (C21H28O3), 15α-Hydroxy-Δ4-tibolone (C21H28O3), 6α-Hydroxy-Δ1,4-tibolone (C21H28O3) and 6β-Methoxy-Δ4-tibolone (C22H30O3) by growing Gibberella fujikuroi (ATCC 10704) in a nutrient media containing tibolone.
Dependencies are inferred from the claim text.