US 8,148,556 B2Granted

Method of producing tibolone metabolites by fermentation with Rhizopus stolonifer

OwnerAttaur Rahman, Muhammed Iqbal Choudhary +2inventors

InventorsAttaur Rahman, Muhammed Iqbal Choudhary, Syed Adnan Ali Shah, Shamsun Nahar Khan

Life of this patent

Estimating the term…

Abstract

A new method of producing metabolites of tibolone comprising fermenting tibolone with Rhizopus stolonifer (ATCC 12938) resulting in the formation of Δ4-Tibolone (C21H28O2), 6β-Hydroxytibolone, and 15β-Hydroxytibolone (C21H28O3) is reported.

Claims1

Dependent claims

A microbial method of producing 6β-Hydroxytibolone, 15β-Hydroxytibolone, and Δ4-Tibolone by growing Rhizopus stolonifer (TSY 0471) in a nutrient media containing tibolone.

Dependencies are inferred from the claim text.

Facts

Application: 13/015,551Filed 27 Jan 2011 · division
Priority: 23 Nov 2007
Published: US 2011/0124041 A126 May 2011
Granted: 3 Apr 2012
Term ends: Not estimatedThe source records don’t support an estimate.

Classification12 codes

C07J 7/00
Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17
A61P 3/10
For glucose homeostasis: for hyperglycaemia, e.g. antidiabetics
C12N 9/99
Enzymes; Proenzymes; Compositions thereof ; Processes for preparing, activating, inhibiting, separating or purifying enzymes: enzyme inactivation…
C12P 33/00
Preparation of steroids

Family

Application11/944,475Parent of this division · filed 23 Nov 2007
US 2011/0124041 A1Pre-grant publication · published 26 May 2011
US 2009/0137542 A1Published application
US 8,148,556 B2This patent

From the US filing history. Foreign family members aren’t listed.

Timeline

Citations

Open elsewhere

patentgrep

Loading patent…