Transgene delivering retrovirus targeting collagen exposed at site of tissue injury
AssigneeUniversity of Southern California
InventorsFrederick L. Hall, Erlinda M. Gordon
Life of this patent
Estimating the term…
Abstract
A viral or non-viral vector particle having a modified viral surface protein wherein the viral surface protein is modified to include a targeting polypeptide including a binding region which binds to an extracellular matrix component. Such vector particles are useful in delivering genes encoding therapeutic agents to cells located at the site of an exposed extracellular matrix component.
Claims7
A recombinant modified polynucleotide encoding a modified viral envelope protein for targeting a viral vector to an extracellular matrix, wherein the modified viral envelope protein includes a targeting polypeptide comprising a binding region which binds to collagen.
Dependencies are inferred from the claim text.