# US 8,148,367 B2 · Renin inhibitors

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- Number: US 8,148,367 B2
- Document ID: US8148367B2
- Status: Granted
- Kind: B2
- Application number: 12/522,888
- Filed: 2008-01-09
- Published: 2010-04-29
- Granted: 2012-04-03
- Earliest claimed: 2008-01-09
- Assignees: Takeda Pharmaceutical Company Limited
- Inventors: Lily Kwok; Betty Lam; Zhe Li; Zhiyuan Zhang
- Web page: https://patentgrep.com/patent/US8148367B2

## CPC

- C07D 233/90: Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 35/00: Antineoplastic agents
- C07D 401/04: directly linked by a ring-member-to-ring-member bond
- C07D 401/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D 401/12: linked by a chain containing hetero atoms as chain links
- C07D 401/14: containing three or more hetero rings
- C07D 403/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D 413/14: containing three or more hetero rings
- C07D 417/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D 417/14: containing three or more hetero rings
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Disclosed are compounds, pharmaceutical compositions, kits, articles of manufacture, methods of using, and methods of preparing compounds having the formula: wherein the variables are as defined herein. The disclosed compounds are inhibitors of Renin.

## Claims

### Claim 1

A compound of the formula
or a pharmaceutically acceptable salt thereof, wherein
Ca denotes a carbon atom;
Na denotes a nitrogen atom;
R1 is selected from
wherein
m is 0, 1, 2, 3 or 4;
l is 0, 1, 2 or 3; and
each R13 is selected from alkyl, halo, and alkoxy;
R2 is selected from methyl, isobutyl, —CH2C(O)NH2, —CH2CH2OCH3, —CH2CH2═CH2,
wherein
R40 is selected from H, fluoro, chloro, methyl, and methoxy; and
R41 is selected from isopropyl and isobutyl;
R3 is selected from
wherein
R24 is selected from hydrogen, alkyl, aryl, and heteroaryl;
R37 is selected from hydrogen, (C1-8)alkyl, (C1-4)alkoxy(C1-8)alkyl; and
R38 is selected from (C1-8)alkyl, (C1-4)alkoxy(C1-8)alkyl, and —(C1-8)alkyl-NHC(O)(C1-4)alkyl;
R4 is selected from hydrogen, (C1-6)alkyl, —CH2N(R28)C(O)R29, —(CH2)nOR28,
wherein
n is 1, 2, or 3;
R28 is hydrogen; and
R29 is phenyl.

### Claim 2 (depends on 1)

The compound according to claim 1, wherein R1 is a fluoro or chloro substituted phenyl or benzyl.

### Claim 3 (depends on 1)

The compound according to claim 1, wherein R1 is selected from the group consisting of isopropyl, cyclopropyl, and cyclopropylmethyl.

### Claim 4 (depends on 1)

The compound according to claim 1, wherein R2 is selected from methyl, —CH2CH2═CH2,

### Claim 5 (depends on 1)

The compound according to claim 1, wherein R2 is selected from isobutyl, —CH2C(O)NH2, —CH2CH2═CH2,
wherein R40 is selected from H, fluoro, chloro, methyl, and methoxy.

### Claim 6 (depends on 1)

The compound according to claim 1, wherein R2 is selected from —CH2CH2═CH2,

### Claim 7 (depends on 1)

The compound according to claim 1, wherein R2 is selected from methyl, —CH2C(O)NH2, —CH2CH2═CH2,

### Claim 8 (depends on 1)

The compound according to claim 1, wherein R3 is selected from:

### Claim 9 (depends on 1)

The compound according to claim 1, wherein R3 is selected from:

### Claim 10 (depends on 1)

The compound according to claim 1, wherein
R1 is phenyl;
R3 is selected from
and
R4 is selected from

### Claim 11

A compound selected from:
(S)-1-((2-Chloro-6-(3-hydroxypyrrolidin-1-yl)pyridin-4-yl)methyl)-3-cyclohexyl-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
(R)-1-((2-Chloro-6-(3-hydroxypyrrolidin-1-yl)pyridin-4-yl)methyl)-3-cyclohexyl-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-((2,6-bis((R)-3-Hydroxypyrrolidin-1-yl)pyridin-4-yl)methyl)-3-cyclohexyl-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-((2,6-bis((S)-3-Hydroxypyrrolidin-1-yl)pyridin-4-yl)methyl)-3-cyclohexyl-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-Cyclohexyl-3-((2,6-di(2methoxyl-pyridine-4-yl)pyridin-4-yl)methyl)-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-Cyclohexyl-3-((6′-methoxy-2,3′-bipyridin-4-yl)methyl)-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-((6-Chloro-6′-methoxy-2,3′-bipyridin-4-yl)methyl)-3-cyclohexyl-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-Cyclohexyl-3-((6-(dimethylamino)-6′-methoxy-2,3′-bipyridin-4-yl)methyl)-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-Cyclohexyl-3-((6-(diethylamino)-6′-methoxy-2,3′-bipyridin-4-yl)methyl)-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1,5-Diphenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
5-Phenyl-4-(piperazine-1-carbonyl)-1-(pyridin-2-yl)-1H-imidazol-2(3H)-one;
4-(2-(Hydroxymethyl)piperazine-1-carbonyl)-1,5-diphenyl-1H-imidazol-2(3H)-one;
5-(3-Fluorophenyl)-1-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(3-Morpholinophenyl)-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
5-Isopropyl-1-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
5-Cyclopropyl-1-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
5-(Cyclopropylmethyl)-1-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
5-(2-Chlorophenyl)-1-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
5-(3-Chlorophenyl)-1-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
5-(4-Chlorophenyl)-1-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-Cyclohexyl-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
Benzyl 3-(2-oxo-5-phenyl-4-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)piperidine-1-carboxylate;
1-((1R,2R)-2-(Benzyloxy)cyclohexyl)-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(2-(2-Methoxyethoxy)phenyl)-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(2-(3-Methoxypropoxy)phenyl)-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(3-(2-Methoxyethoxy)phenyl)-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(3-(3-Methoxypropoxy)phenyl)-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(6-(3-Methoxypropoxy)pyridin-2-yl)-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
(R)-1-Cyclohexyl-4-(3-methylpiperazine-1-carbonyl)-5-phenyl-1H-imidazol-2(3H)-one;
1-Cyclohexyl-4-(3-methylpiperazine-1-carbonyl)-5-phenyl-1H-imidazol-2(3H)-one;
(S)-1-Cyclohexyl-4-(3-methylpiperazine-1-carbonyl)-5-phenyl-1H-imidazol-2(3H)-one;
1-Cyclohexyl-4-(3,5-dimethylpiperazine-1-carbonyl)-5-phenyl-1H-imidazol-2(3H)-one;
1-Cyclohexyl-4-(2,5-dimethylpiperazine-1-carbonyl)-5-phenyl-1H-imidazol-2(3H)-one;
5-(3-Chlorophenyl)-1-(3-(3-methoxypropoxy)phenyl)-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
5-(3-Chlorophenyl)-1-(3-(2-methoxyethoxy)phenyl)-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(1H-Benzo[d]imidazol-2-yl)-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-Benzyl-3,4-diphenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-Benzyl-4-phenyl-5-(piperazine-1-carbonyl)-3-(pyridin-2-yl)-1H-imidazol-2(3H)-one;
1-((5-Methylisoxazol-3-yl)methyl)-3,4-diphenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-((5-Cyclopropyl-1,3,4-thiadiazol-2-yl)methyl)-3,4-diphenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-((1H-Imidazol-4-yl)methyl)-3,4-diphenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-((2-Aminothiazol-4-yl)methyl)-3,4-diphenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(3-Fluorobenzyl)-3,4-diphenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(3,4-Difluorobenzyl)-3,4-diphenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1,5-Diphenyl-4-(piperazine-1-carbonyl)-3-((tetrahydro-2H-pyran-4-yl)methyl)-1H-imidazol-2(3H)-one;
1-Methyl-3,4-diphenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
(R)-4-(2-Benzylpiperazine-1-carbonyl)-3-methyl-1-(3-morpholinophenyl)-5-phenyl-1H-imidazol-2(3H)-one;
1-Benzyl-3-(3-morpholinophenyl)-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(3-(Morpholine-4-carbonyl)benzyl)-3-(3-morpholinophenyl)-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(3-Morpholinophenyl)-5-phenyl-4-(piperazine-1-carbonyl)-3-(3-(piperidine-1-carbonyl)benzyl)-1H-imidazol-2(3H)-one;
2-(3-((3-(3-Morpholinophenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)methyl)phenoxy)acetic acid;
1-Cyclohexyl-3-methyl-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-Allyl-3-cyclohexyl-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
2-(3-Cyclohexyl-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)acetamide;
(R)-1-Allyl-5-(2-benzylpiperazine-1-carbonyl)-3-cyclohexyl-4-phenyl-1H-imidazol-2(3H)-one;
(R)-4-(2-Benzylpiperazine-1-carbonyl)-1-cyclohexyl-3-methyl-5-phenyl-1H-imidazol-2(3H)-one;
(R)-4-(2-Benzylpiperazine-1-carbonyl)-1-cyclohexyl-3-(2-methoxyethyl)-5-phenyl-1H-imidazol-2(3H)-one;
(R)-2-(5-(2-Benzylpiperazine-1-carbonyl)-3-cyclohexyl-2-oxo-4-phenyl-2,3-dihydro-1H-imidazol-1-yl)acetamide;
Methyl 2-(3-cyclohexyl-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)-2-phenylacetate;
1-Cyclohexyl-5-phenyl-3-(1-phenylethyl)-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
(R)-4-(2-Benzylpiperazine-1-carbonyl)-1-cyclohexyl-3-methyl-5-phenyl-1H-imidazol-2(3H)-one;
1-Cyclohexyl-3-phenethyl-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(3-(1H-Pyrrol-1-yl)benzyl)-3-cyclohexyl-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
(R)-2-(5-(2-Benzylpiperazine-1-carbonyl)-2-oxo-3,4-diphenyl-2,3-dihydro-1H-imidazol-1-yl)acetamide;
1-(3-Morpholinophenyl)-3-(3-phenoxybenzyl)-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(3-(3-Methoxypropoxy)phenyl)-3-(3-phenoxybenzyl)-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(3-(Benzyloxy)benzyl)-3-(3-morpholinophenyl)-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(3-(1H-Pyrrol-1-yl)benzyl)-3-(3-morpholinophenyl)-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
N-Isobutyl-N-methyl-3-((3-(3-morpholinophenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)methyl)benzamide;
3-((2-oxo-3,4-Diphenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)methyl)benzonitrile;
Methyl 3-((2-oxo-3,4-Diphenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)methyl)benzoate;
1-Benzyl-4-phenyl-5-(piperazine-1-carbonyl)-3-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-2(3H)-one;
1,5-Diphenyl-4-(piperazine-1-carbonyl)-3-(quinolin-8-ylmethyl)-1H-imidazol-2(3H) one;
1-(3-Methoxybenzyl)-3,4-diphenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(Naphthalen-2-ylmethyl)-3,4-diphenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
2-((2-oxo-3,4-Diphenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)methyl)benzonitrile;
1-(3,5-Dimethoxybenzyl)-3,4-diphenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(4-Chloro-3-(trifluoromethoxy)benzyl)-3,4-diphenyl-5-(piperazine-1-carbonyl)-1H imidazol-2(3H)-one;
1-(3-(1H-Pyrrol-1-yl)benzyl)-3,4-diphenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-((2-Chloro-6-morpholinopyridin-4-yl)methyl)-3-cyclohexyl-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-Cyclohexyl-3-((2,6-di(1H-pyrazol-4-yl)pyridin-4-yl)methyl)-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(1-Acetylpiperidin-3-yl)-3-(3-methoxybenzyl)-5-phenyl-4-(piperazine-1 carbonyl)-1H-imidazol-2(3H)-one;
1-(1-Acetylpiperidin-3-yl)-3-benzyl-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(1-Acetylpiperidin-3-yl)-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(1-Benzoylpiperidin-3-yl)-3-benzyl-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-Benzyl-4-phenyl-3-(1-(phenylsulfonyl)piperidin-3-yl)-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-Benzyl-3-(1-(furan-2-carbonyl)piperidin-3-yl)-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
5-Phenyl-1-(1-(phenylsulfonyl)piperidin-3-yl)-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(1-Acetylpiperidin-3-yl)-3-(3-phenoxybenzyl)-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-Benzyl-4-phenyl-3-(1-(phenylsulfonyl)piperidin-3-yl)-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-Benzyl-4-phenyl-5-(piperazine-1-carbonyl)-3-(1-(pyridin-2-ylsulfonyl)piperidin-3-yl)-1H-imidazol-2(3H)-one;
1-(3-Phenoxybenzyl)-4-phenyl-3-(1-(phenylsulfonyl)piperidin-3-yl)-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(3-Phenoxybenzyl)-4-phenyl-5-(piperazine-1-carbonyl)-3-(1-(pyridin-2-ylsulfonyl)piperidin-3-yl)-1H-imidazol-2(3H)-one;
1-(1-Acetylpiperidin-3-yl)-4-((R)-2-benzylpiperazine-1-carbonyl)-5-phenyl-1H-imidazol-2(3H)-one;
1-Benzyl-3-((1R,2R)-2-hydroxycyclohexyl)-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-((1R,2R)-2-Hydroxycyclohexyl)-3-(3-phenoxybenzyl)-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
N—(((S)-1-(1-((1R,2R)-2-Hydroxycyclohexyl)-2-oxo-5-phenyl-2,3-dihydro-1H-imidazole-4-carbonyl)piperazin-2-yl)methyl)benzamide;
(S)—N-((1-(1-Cyclohexyl-2-oxo-5-phenyl-2,3-dihydro-1H-imidazole-4-carbonyl)piperazin-2-yl)methyl)benzamide;
(R)-4-(2-Benzylpiperazine-1-carbonyl)-1,5-diphenyl-1H-imidazol-2(3H)-one;
(R)-4-(2-Benzylpiperazine-1-carbonyl)-1-(3-morpholinophenyl)-5-phenyl-1H-imidazol-2(3H)-one;
(R)-4-(2-Benzylpiperazine-1-carbonyl)-1-cyclohexyl-5-phenyl-1H-imidazol-2(3H)-one;
(R)-4-(2-Benzylpiperazine-1-carbonyl)-1-(2,3-dimethoxyphenyl)-5-phenyl-1H-imidazol-2(3H)-one;
(R)-4-(2-Benzylpiperazine-1-carbonyl)-1-(2-methoxyphenyl)-5-phenyl-1H-imidazol-2(3H)-one;
(R)-4-(2-Benzylpiperazine-1-carbonyl)-1-(3-(methylsulfonyl)phenyl)-5-phenyl-1H-imidazol-2(3H)-one;
1-(1-Acetylpiperidin-3-yl)-4-((R)-2-benzylpiperazine-1-carbonyl)-5-phenyl-1H-imidazol-2(3H)-one;
(R)-4-(2-Benzylpiperazine-1-carbonyl)-5-phenyl-1-o-tolyl-1H-imidazol-2(3H)-one;
(R)-4-(2-Benzylpiperazine-1-carbonyl)-1-(2-nitrophenyl)-5-phenyl-1H-imidazol-2(3H)-one;
(R)—N-(2-(4-(2-Benzylpiperazine-1-carbonyl)-2-oxo-5-phenyl-2,3-dihydro-1H-imidazol-1-yl)phenyl)methanesulfonamide;
(R)—N-(2-(4-(2-Benzylpiperazine-1-carbonyl)-2-oxo-5-phenyl-2,3-dihydro-1H-imidazol-1-yl)phenyl)propane-1-sulfonamide;
(R)—N-(2-(4-(2-Benzylpiperazine-1-carbonyl)-2-oxo-5-phenyl-2,3-dihydro-1H-imidazol-1-yl)phenyl)cyclopropanecarboxamide;
(R)—N-(2-(4-(2-Benzylpiperazine-1-carbonyl)-2-oxo-5-phenyl-2,3-dihydro-1H-imidazol-1-yl)phenyl)butyramide;
(R)—N-(2-(4-(2-Benzylpiperazine-1-carbonyl)-2-oxo-5-phenyl-2,3-dihydro-1H-imidazol-1-yl)phenyl)acetamide;
(R)—N-(2-(4-(2-Benzylpiperazine-1-carbonyl)-2-oxo-5-phenyl-2,3-dihydro-1H-imidazol-1-yl)phenyl)cyclopropanesulfonamide;
(R)—N-(2-(4-(2-Benzylpiperazine-1-carbonyl)-2-oxo-5-phenyl-2,3-dihydro-1H-imidazol-1-yl)phenyl)benzamide;
(R)—N-(2-(4-(2-Benzylpiperazine-1-carbonyl)-2-oxo-5-phenyl-2,3-dihydro-1H-imidazol-1-yl)phenyl)Benzenesulfonamide;
4-((R)-2-Benzylpiperazine-1-carbonyl)-1-((1S,2S)-2-hydroxycyclohexyl)-5-phenyl-1H-imidazol-2(3H)-one;
(R)—N-(2-(4-(2-Benzylpiperazine-1-carbonyl)-2-oxo-5-phenyl-2,3-dihydro-1H-imidazol-1-yl)phenyl)ethanesulfonamide;
(R)—N-(2-(4-(2-Benzylpiperazine-1-carbonyl)-2-oxo-5-phenyl-2,3-dihydro-1H-imidazol-1-yl)phenyl)butane-1-sulfonamide;
(R)—N-(2-(4-(2-Benzylpiperazine-1-carbonyl)-2-oxo-5-phenyl-2,3-dihydro-1H-imidazol-1-yl)phenyl)prop-2-ene-1-sulfonamide;
(R)-4-(2-Benzylpiperazine-1-carbonyl)-1-((1-hydroxycyclohexyl)methyl)-5-phenyl-1H-imidazol-2(3H)-one;
(R)-4-(2-Benzylpiperazine-1-carbonyl)-5-phenyl-1-(1,2,3,4-tetrahydroquinolin-7-yl)-1H-imidazol-2(3H)-one;
(R)-4-(2-Benzylpiperazine-1-carbonyl)-5-phenyl-1-(1,2,3,4-tetrahydroquinolin-7-yl)-1H-imidazol-2(3H)-one;
(R)-4-(2-Benzylpiperazine-1-carbonyl)-1-(1-butyl-1,2,3,4-tetrahydroquinolin-7-yl)-5-cyclopropyl-1H-imidazol-2(3H)-one;
(R)-4-(2-Benzylpiperazine-1-carbonyl)-5-cyclopropyl-1-(1,2,3,4-tetrahydroquinolin-7-yl)-1H-imidazol-2(3H)-one;
(R)-4-(2-Benzylpiperazine-1-carbonyl)-1-(4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-5-phenyl-1H-imidazol-2(3H)-one;
(R)-4-(2-Benzylpiperazine-1-carbonyl)-1-(indolin-6-yl)-5-phenyl-1H-imidazol-2(3H)-one;
(R)-4-(2-Benzylpiperazine-1-carbonyl)-1-(4-(2-methoxyethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-5-phenyl-1H-imidazol-2(3H)-one;
4-((R)-2-Benzylpiperazine-1-carbonyl)-1-(3-methoxy-2,3-dihydro-1H-inden-5-yl)-5-phenyl-1H-imidazol-2(3H)-one;
(R)-4-(2-(2-Phenoxyethyl)piperazine-1-carbonyl)-5-phenyl-1-(1,2,3,4-tetrahydroquinolin-7-yl)-1H-imidazol-2(3H)-one;
1-Allyl-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-1H-imidazol-2(3H)-one;
1-(3-Phenoxybenzyl)-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-1H-imidazol-2(3H)-one;
1-(3-Methoxybenzyl)-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-1H-imidazol-2(3H)-one;
1-(3,4-Difluorobenzyl)-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-1H-imidazol-2(3H)-one;
1-Allyl-3-(2-methoxyphenyl)-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(2-Methoxyphenyl)-3-(3-phenoxybenzyl)-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(3-Methoxybenzyl)-3-(2-methoxyphenyl)-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(3,4-Difluorobenzyl)-3-(2-methoxyphenyl)-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(3-(2-Phenoxyethoxy)benzyl)-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-1H-imidazol-2(3H)-one;
1-Allyl-3-(3-morpholinophenyl)-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(3-Methoxybenzyl)-3-(3-morpholinophenyl)-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-((1S,2R)-2-Hydroxycyclohexyl)-3-(3-phenoxybenzyl)-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-((1S,2R)-2-Hydroxycyclohexyl)-3-(3-methoxybenzyl)-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(3,4-Difluorobenzyl)-3-((1S,2R)-2-hydroxycyclohexyl)-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
N-(2-(2-oxo-4-Phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)benzenesulfonamide;
N-(3-(2-oxo-4-Phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)benzamide;
1-(Cyclohexylmethyl)-3-((1S,2R)-2-hydroxycyclohexyl)-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
N-(2-(3-(2-Methoxyphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)ethyl)benzenesulfonamide;
N-(3-(3-(2-Methoxyphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)propyl)benzamide;
1-(Cyclohexylmethyl)-3-(2-methoxyphenyl)-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
N-(3-(3-(2-Methoxyphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)propyl)benzenesulfonamide;
N-(3-(2-oxo-4-Phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)benzenesulfonamide;
1-(Cyclohexylmethyl)-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-1H-imidazol-2(3H)-one;
1-(3,4-Difluorobenzyl)-3-(3-(3-methoxypropoxy)phenyl)-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
3-Methyl-N-(3-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)butanamide;
N-(2-(2-oxo-4-Phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)benzamide;
N-(3-(3-(2-Methoxyphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)propyl)-3-methylbutanamide;
N-(2-(3-(2-Methoxyphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)ethyl)benzamide;
N-(2-(3-(2-Methoxyphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)ethyl)-3-methylbutanamide;
N-(3-(3-((2S)-2-Hydroxycyclohexyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)propyl)benzamide;
N-(3-(3-((2S)-2-Hydroxycyclohexyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)propyl)benzenesulfonamide;
N-(3-(3-((2S)-2-Hydroxycyclohexyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)propyl)-3-methylbutanamide;
N-(2-(3-((2S)-2-Hydroxycyclohexyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)ethyl)-3-methylbutanamide;
N-(3-(3-(3-Morpholinophenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazolidin-1-yl)propyl)benzamide;
N-(3-(3-(3-Morpholinophenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)propyl)benzenesulfonamide;
3-Methyl-N-(3-(3-(3-morpholinophenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)propyl)butanamide;
N-(2-(3-(3-Morpholinophenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)ethyl)benzamide;
3-Methyl-N-(2-(3-(3-morpholinophenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)ethyl)butanamide;
N-(3-(3-(3-(3-Methoxypropoxy)phenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)propyl)benzamide;
N-(3-(3-(3-(3-Methoxypropoxy)phenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)propyl)benzenesulfonamide;
N-(3-(3-(3-(3-Methoxypropoxy)phenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)propyl)-3-methylbutanamide;
N-(2-(3-(3-(3-Methoxypropoxy)phenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)ethyl)benzamide;
N-(2-(3-(3-(3-Methoxypropoxy)phenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)ethyl)benzenesulfonamide;
N-(2-(3-(3-(3-Methoxypropoxy)phenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)ethyl)-3-methylbutanamide;
N-(2-(3-(3-Morpholinophenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)ethyl)benzenesulfonamide;
1-(3-(2-Methoxyethoxy)benzyl)-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-1H-imidazol-2(3H)-one;
1-(3-(2-Methoxyethoxy)benzyl)-3-(2-methoxyphenyl)-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(2-Methoxyphenyl)-3-(3-(2-phenoxyethoxy)benzyl)-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(Cyclohexylmethyl)-3-(3-morpholinophenyl)-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(3,4-Difluorobenzyl)-3-(3-morpholinophenyl)-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(3-Morpholinophenyl)-3-(3-(2-phenoxyethoxy)benzyl)-5-phenyl-4-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
1-(3-(2-Methoxyethoxy)benzyl)-3-(3-(3-methoxypropoxy)phenyl)-4-phenyl-5-(piperazine-1-carbonyl)-1H-imidazol-2(3H)-one;
2-Fluoro-N-(3-(3-(3-morpholinophenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)propyl)benzenesulfonamide;
2-Chloro-N-(3-(3-(3-morpholinophenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)propyl)benzenesulfonamide;
3-Chloro-N-(3-(3-(3-morpholinophenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)propyl)benzenesulfonamide;
N-(3-(3-(3-Morpholinophenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)propyl)propane-2-sulfonamide;
2-Methyl-N-(3-(3-(3-morpholinophenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)propyl)benzenesulfonamide;
3-Methoxy-N-(3-(3-(3-morpholinophenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)propyl)benzenesulfonamide;
4-Methoxy-N-(3-(3-(3-morpholinophenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)propyl)benzenesulfonamide;
1-(3-(3-(3-Morpholinophenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)propyl)-3-phenylurea;
1-Isopropyl-3-(3-(3-(3-morpholinophenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)propyl)urea;
4-Chloro-N-(3-(3-(3-morpholinophenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-2,3-dihydro-1H-imidazol-1-yl)propyl)benzenesulfonamide;
2-Fluoro-N-(2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)benzenesulfonamide;
2-Chloro-N-(2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)benzenesulfonamide;
3-Chloro-N-(2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)benzenesulfonamide;
4-Chloro-N-(2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)benzenesulfonamide;
N-(2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)propane-2-sulfonamide;
2-Methyl-N-(2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)benzenesulfonamide;
3-Methoxy-N-(2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)benzenesulfonamide;
4-Methoxy-N-(2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)benzenesulfonamide;
1-(2-(2-Oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)-3-phenylurea;
1-(2-Chlorophenyl)-3-(2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)urea;
1-(4-Chlorophenyl)-3-(2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)urea;
1-(2-Methoxyphenyl)-3-(2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)urea;
1-(3-Methoxyphenyl)-3-(2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)urea;
1-Isopropyl-3-(2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)urea;
2-Chloro-N-(3-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)benzenesulfonamide;
3-Chloro-N-(3-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)benzenesulfonamide;
4-Chloro-N-(3-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)benzenesulfonamide;
2-Methyl-N-(3-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)benzenesulfonamide;
3-Methoxy-N-(3-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)benzenesulfonamide;
4-Methoxy-N-(3-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)benzenesulfonamide;
1-(3-(2-Oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)-3-phenylurea;
1-(2-Chlorophenyl)-3-(3-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)urea;
1-(2-Methoxyphenyl)-3-(3-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)urea;
1-(3-Methoxyphenyl)-3-(3-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)urea;
1-Isopropyl-3-(3-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)urea;
1-(4-Methoxyphenyl)-3-(2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)urea;
2-Fluoro-N-(3-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)benzenesulfonamide;
2-Fluoro-N-(2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)benzamide;
2-Chloro-N-(2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)benzamide;
2-Chloro-N-(2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)benzamide;
3-Chloro-N-(2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)benzamide;
4-Chloro-N-(2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)benzamide;
2-Methoxy-N-(2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)benzamide;
4-Methoxy-N-(2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)benzamide;
N-(2-(2-Oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)isobutyramide;
N-(2-(2-Oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)cyclohexanecarboxamide
3-Methyl-N-(2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethyl)butanamide;
N-(3-(2-Oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)propane-2-sulfonamide;
2-Fluoro-N-(3-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)benzamide;
2-Chloro-N-(3-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)benzamide;
3-Chloro-N-(3-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)benzamide;
4-Chloro-N-(3-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)benzamide;
2-Methoxy-N-(3-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)benzamide;
4-Methoxy-N-(3-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)benzamide;
N-(3-(2-Oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)isobutyramide;
N-(3-(2-Oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propyl)cyclohexanecarboxamide;
Phenyl 2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethylcarbamate;
Methyl 2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethylcarbamate;
Ethyl 2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethylcarbamate;
Benzyl 2-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)ethylcarbamate;
Phenyl 3-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propylcarbamate;
Methyl 3-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propylcarbamate;
Ethyl 3-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propylcarbamate;
Benzyl 3-(2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-o-tolyl-2,3-dihydro-1H-imidazol-1-yl)propylcarbamate;
1-(2-Methylphenyl)-5-phenyl-4-(piperazine-1-carbonyl)-3-prop-2-enyl-imidazol-2-one;
1-(Cyclohexylmethyl)-3-(2-methylphenyl)-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
1-(2-Methylphenyl)-3-[(3-phenoxyphenyl)methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-[(2-Amino1,3-thiazol-4-yl)methyl]-3-(2-methylphenyl)-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
1-[(3-Methoxyphenyl)methyl]-3-(2-methylphenyl)-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
1-[(3,4-Difluorophenyl)methyl]-3-(2-methylphenyl)-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
N-[2-[3-(2-Methylphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]benzamide;
N-[2-[3-(2-Methylphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]benzenesulfonamide;
3-Methyl-N-[2-[3-(2-methylphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]butanamide;
2-Methyl-N-[2-[3-(2-methylphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]propane-1-sulfonamide;
N-[3-[3-(2-Methylphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]benzamide;
N-[3-[3-(2-Methylphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]benzenesulfonamide;
3-Methyl-N-[3-[3-(2-methylphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]butanamide;
2-Methyl-N-[3-[3-(2-methylphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]propane-1-sulfonamide;
1-[[3-(2-Methoxyethoxy)phenyl]methyl]-3-(2-methylphenyl)-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
1-(2-Methylphenyl)-5-phenyl-4-(piperazine-1-carbonyl)-3-[[3-(2-pyridin-3-yloxyethoxy)phenyl]methyl]imidazol-2-one;
1-(2-Methylphenyl)-5-phenyl-4-(piperazine-1-carbonyl)-3-[[3-(2-propan-2-yloxyethoxy)phenyl]methyl]imidazol-2-one;
1-(2-Methylphenyl)-3-[[3-(2-phenoxyethoxy)phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-(2-Methylphenyl)-3-[[3-(2-morpholin-4-yl-2-oxo-ethoxy)phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-(2-Methylphenyl)-3-[[3-[2-oxo-2-(1-piperidyl)ethoxy]phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
N-Methyl-2-[3-[[3-(2-methylphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]methyl]phenoxy]acetamide;
2-[3-[[3-(2-Methylphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]methyl]phenoxy]-N-propan-2-yl-acetamide;
1-(2-Methoxyphenyl)-5-phenyl-4-(piperazine-1-carbonyl)-3-prop-2-enyl-imidazol-2-one;
1-(Cyclohexylmethyl)-3-(2-methoxyphenyl)-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
1-(2-Methoxyphenyl)-3-[(3-phenoxyphenyl)methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-[(2-Amino1,3-thiazol-4-yl)methyl]-3-(2-methoxyphenyl)-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
1-(2-Methoxyphenyl)-3-[(3-methoxyphenyl)methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-[(3,4-Difluorophenyl)methyl]-3-(2-methoxyphenyl)-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
N-[2-[3-(2-Methoxyphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]benzamide;
N-[2-[3-(2-Methoxyphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]benzenesulfonamide;
N-[2-[3-(2-Methoxyphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]-3-methyl-butanamide;
N-[2-[3-(2-Methoxyphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]-2-methyl-propane-1-sulfonamide;
N-[3-[3-(2-Methoxyphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]benzamide;
N-[3-[3-(2-Methoxyphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]benzenesulfonamide;
N-[3-[3-(2-Methoxyphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]-3-methyl-butanamide;
N-[3-[3-(2-Methoxyphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]-2-methyl-propane-1-sulfonamide;
1-[[3-(2-Methoxyethoxy)phenyl]methyl]-3-(2-methoxyphenyl)-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
1-(2-Methoxyphenyl)-5-phenyl-4-(piperazine-1-carbonyl)-3-[[3-(2-pyridin-3-yloxyethoxy)phenyl]methyl]imidazol-2-one;
1-(2-Methoxyphenyl)-5-phenyl-4-(piperazine-1-carbonyl)-3-[[3-(2-propan-2-yloxyethoxy)phenyl]methyl]imidazol-2-one;
1-(2-Methoxyphenyl)-3-[[3-(2-phenoxyethoxy)phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-(2-Methoxyphenyl)-3-[[3-(2-morpholin-4-yl-2-oxo-ethoxy)phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-(2-Methoxyphenyl)-3-[[3-[2-oxo-2-(1-piperidyl)ethoxy]phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
2-[3-[[3-(2-Methoxyphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]methyl]phenoxy]-N-methyl-acetamide;
2-[3-[[3-(2-Methoxyphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]methyl]phenoxy]-N-propan-2-yl-acetamide;
1-(3-Morpholin-4-ylphenyl)-5-phenyl-4-(piperazine-1-carbonyl)-3-prop-2-enyl-imidazol-2-one;
1-(Cyclohexylmethyl)-3-(3-morpholin-4-ylphenyl)-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
1-(3-Morpholin-4-ylphenyl)-3-[(3-phenoxyphenyl)methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-[(2-Amino1,3-thiazol-4-yl)methyl]-3-(3-morpholin-4-ylphenyl)-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
1-[(3-Methoxyphenyl)methyl]-3-(3-morpholin-4-ylphenyl)-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
1-[(3,4-Difluorophenyl)methyl]-3-(3-morpholin-4-ylphenyl)-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
N-[2-[3-(3-Morpholin-4-ylphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]benzamide;
N-[2-[3-(3-Morpholin-4-ylphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]benzenesulfonamide;
3-Methyl-N-[2-[3-(3-morpholin-4-ylphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]butanamide;
2-Methyl-N-[2-[3-(3-morpholin-4-ylphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]propane-1-sulfonamide;
N-[3-[3-(3-Morpholin-4-ylphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]benzamide;
N-[3-[3-(3-Morpholin-4-ylphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]benzenesulfonamide;
3-Methyl-N-[3-[3-(3-morpholin-4-ylphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]butanamide;
2-Methyl-N-[3-[3-(3-morpholin-4-ylphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]propane-1-sulfonamide;
1-[[3-(2-Methoxyethoxy)phenyl]methyl]-3-(3-morpholin-4-ylphenyl)-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
1-(3-Morpholin-4-ylphenyl)-5-phenyl-4-(piperazine-1-carbonyl)-3-[[3-(2-pyridin-3-yloxyethoxy)phenyl]methyl]imidazol-2-one;
1-(3-Morpholin-4-ylphenyl)-5-phenyl-4-(piperazine-1-carbonyl)-3-[[3-(2-propan-2-yloxyethoxy)phenyl]methyl]imidazol-2-one
1-(3-Morpholin-4-ylphenyl)-3-[[3-(2-phenoxyethoxy)phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-[[3-(2-Morpholin-4-yl-2-oxo-ethoxy)phenyl]methyl]-3-(3-morpholin-4-ylphenyl)-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
1-(3-Morpholin-4-ylphenyl)-3-[[3-[2-oxo-2-(1-piperidyl)ethoxy]phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
N-Methyl-2-[3-[[3-(3-morpholin-4-ylphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]methyl]phenoxy]acetamide;
2-[3-[[3-(3-Morpholin-4-ylphenyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]methyl]phenoxy]-N-propan-2-yl-acetamide;
1-[3-(3-Methoxypropoxy)phenyl]-5-phenyl-4-(piperazine-1-carbonyl)-3-prop-2-enyl-imidazol-2-one;
1-(Cyclohexylmethyl)-3-[3-(3-methoxypropoxy)phenyl]-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
1-[3-(3-Methoxypropoxy)phenyl]-3-[(3-phenoxyphenyl)methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-[(2-Amino1,3-thiazol-4-yl)methyl]-3-[3-(3-methoxypropoxy)phenyl]-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
1-[(3-Methoxyphenyl)methyl]-3-[3-(3-methoxypropoxy)phenyl]-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
1-[(3,4-Difluorophenyl)methyl]-3-[3-(3-methoxypropoxy)phenyl]-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
N-[2-[3-[3-(3-Methoxypropoxy)phenyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]benzamide;
N-[2-[3-[3-(3-Methoxypropoxy)phenyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]benzenesulfonamide;
N-[2-[3-[3-(3-Methoxypropoxy)phenyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]-3-methyl-butanamide;
N-[2-[3-[3-(3-Methoxypropoxy)phenyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]-2-methyl-propane-1-sulfonamide;
N-[3-[3-[3-(3-Methoxypropoxy)phenyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]benzamide;
N-[3-[3-[3-(3-Methoxypropoxy)phenyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]benzenesulfonamide;
N-[3-[3-[3-(3-Methoxypropoxy)phenyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]-3-methyl-butanamide;
N-[3-[3-[3-(3-Methoxypropoxy)phenyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]-2-methyl-propane-1-sulfonamide;
1-[[3-(2-Methoxyethoxy)phenyl]methyl]-3-[3-(3-methoxypropoxy)phenyl]-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
1-[3-(3-Methoxypropoxy)phenyl]-5-phenyl-4-(piperazine-1-carbonyl)-3-[[3-(2-pyridin-3-yloxyethoxy)phenyl]methyl]imidazol-2-one;
1-[3-(3-Methoxypropoxy)phenyl]-5-phenyl-4-(piperazine-1-carbonyl)-3-[[3-(2-propan-2-yloxyethoxy)phenyl]methyl]imidazol-2-one;
1-[3-(3-Methoxypropoxy)phenyl]-3-[[3-(2-phenoxyethoxy)phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-[3-(3-Methoxypropoxy)phenyl]-3-[[3-(2-morpholin-4-yl-2-oxo-ethoxy)phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-[3-(3-Methoxypropoxy)phenyl]-3-[[3-[2-oxo-2-(1-piperidyl)ethoxy]phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
2-[3-[[3-[3-(3-Methoxypropoxy)phenyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]methyl]phenoxy]-N-methyl-acetamide;
2-[3-[[3-[3-(3-Methoxypropoxy)phenyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]methyl]phenoxy]-N-propan-2-yl-acetamide;
N-[(1S)-2-[2-oxo-5-Phenyl-4-(piperazine-1-carbonyl)-3-prop-2-enyl-imidazol-1-yl]cyclohexyl]propanamide;
N-[(1S)-2-[3-(Cyclohexylmethyl)-2-oxo-5-phenyl-4-(piperazine-1-carbonyl)imidazol-1-yl]cyclohexyl]propanamide;
N-[(1S)-2-[2-oxo-3-[(3-Phenoxyphenyl)methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-1-yl]cyclohexyl]propanamide;
N-[(1S)-2-[3-[(2-Amino 1,3-thiazol-4-yl)methyl]-2-oxo-5-phenyl-4-(piperazine-1-carbonyl)imidazol-1-yl]cyclohexyl]propanamide;
N-[(1S)-2-[3-[(3-Methoxyphenyl)methyl]-2-oxo-5-phenyl-4-(piperazine-1-carbonyl)imidazol-1-yl]cyclohexyl]propanamide;
N-[(1S)-2-[3-[(3,4-Difluorophenyl)methyl]-2-oxo-5-phenyl-4-(piperazine-1-carbonyl)imidazol-1-yl]cyclohexyl]propanamide;
N-[2-[2-oxo-4-Phenyl-5-(piperazine-1-carbonyl)-3-[(2S)-2-(propanoylamino)cyclohexyl]imidazol-1-yl]ethyl]benzamide;
N-[(1S)-2-[3-[2-(Benzenesulfonamido)ethyl]-2-oxo-5-phenyl-4-(piperazine-1-carbonyl)imidazol-1-yl]cyclohexyl]propanamide;
3-Methyl-N-[2-[2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-[(2S)-2-(propanoylamino)cyclohexyl]imidazol-1-yl]ethyl]butanamide;
N-[(1S)-2-[3-[2-(2-Methylpropylsulfonylamino)ethyl]-2-oxo-5-phenyl-4-(piperazine-1-carbonyl)imidazol-1-yl]cyclohexyl]propanamide;
N-[3-[2-oxo-4-Phenyl-5-(piperazine-1-carbonyl)-3-[(2S)-2-(propanoylamino)cyclohexyl]imidazol-1-yl]propyl]benzamide;
N-[(1S)-2-[3-[3-(Benzenesulfonamido)propyl]-2-oxo-5-phenyl-4-(piperazine-1-carbonyl)imidazol-1-yl]cyclohexyl]propanamide;
3-Methyl-N-[3-[2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-[(2S)-2-(propanoylamino)cyclohexyl]imidazol-1-yl]propyl]butanamide;
N-[(1S)-2-[3-[3-(2-Methylpropylsulfonylamino)propyl]-2-oxo-5-phenyl-4-(piperazine-1-carbonyl)imidazol-1-yl]cyclohexyl]propanamide;
N-[(1S)-2-[3-[[3-(2-Methoxyethoxy)phenyl]methyl]-2-oxo-5-phenyl-4-(piperazine-1-carbonyl)imidazol-1-yl]cyclohexyl]propanamide;
N-[(1S)-2-[2-oxo-5-Phenyl-4-(piperazine-1-carbonyl)-3-[[3-(2-pyridin-3-yloxyethoxy)phenyl]methyl]imidazol-1-yl]cyclohexyl]propanamide;
N-[(1S)-2-[2-oxo-5-Phenyl-4-(piperazine-1-carbonyl)-3-[[3-(2-propan-2-yloxyethoxy)phenyl]methyl]imidazol-1-yl]cyclohexyl]propanamide;
N-[(1S)-2-[2-oxo-3-[[3-(2-Phenoxyethoxy)phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-1-yl]cyclohexyl]propanamide;
N-[(1S)-2-[3-[[3-(2-Morpholin-4-yl-2-oxo-ethoxy)phenyl]methyl]-2-oxo-5-phenyl-4-(piperazine-1-carbonyl)imidazol-1-yl]cyclohexyl]propanamide;
N-[(1S)-2-[2-oxo-3-[[3-[2-oxo-2-(1-Piperidyl)ethoxy]phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-1-yl]cyclohexyl]propanamide;
N-[(1S)-2-[3-[[3-(Methylcarbamoylmethoxy)phenyl]methyl]-2-oxo-5-phenyl-4-(piperazine-1-carbonyl)imidazol-1-yl]cyclohexyl]propanamide;
N-[(1S)-2-[2-oxo-5-Phenyl-4-(piperazine-1-carbonyl)-3-[[3-(propan-2-ylcarbamoylmethoxy)phenyl]methyl]imidazol-1-yl]cyclohexyl]propanamide;
1-(1-Acetyl-3-piperidyl)-5-phenyl-4-(piperazine-1-carbonyl)-3-prop-2-enyl-imidazol-2-one;
1-(1-Acetyl-3-piperidyl)-3-(cyclohexylmethyl)-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-(1-Acetyl-3-piperidyl)-3-[(3-phenoxyphenyl)methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-(1-Acetyl-3-piperidyl)-3-[(2-amino1,3-thiazol-4-yl)methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-(1-Acetyl-3-piperidyl)-3-[(3-methoxyphenyl)methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-(1-Acetyl-3-piperidyl)-3-[(3,4-difluorophenyl)methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
N-[2-[3-(1-Acetyl-3-piperidyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]benzamide;
N-[2-[3-(1-Acetyl-3-piperidyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]benzenesulfonamide;
N-[2-[3-(1-Acetyl-3-piperidyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]-3-methyl-butanamide;
N-[2-[3-(1-Acetyl-3-piperidyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]-2-methyl-propane-1-sulfonamide;
N-[3-[3-(1-Acetyl-3-piperidyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]benzamide;
N-[3-[3-(1-Acetyl-3-piperidyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]benzenesulfonamide;
N-[3-[3-(1-Acetyl-3-piperidyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]-3-methyl-butanamide;
N-[3-[3-(1-Acetyl-3-piperidyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]-2-methyl-propane-1-sulfonamide;
1-(1-Acetyl-3-piperidyl)-3-[[3-(2-methoxyethoxy)phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-(1-Acetyl-3-piperidyl)-5-phenyl-4-(piperazine-1-carbonyl)-3-[[3-(2-pyridin-3-yloxyethoxy)phenyl]methyl]imidazol-2-one;
1-(1-Acetyl-3-piperidyl)-5-phenyl-4-(piperazine-1-carbonyl)-3-[[3-(2-propan-2-yloxyethoxy)phenyl]methyl]imidazol-2-one;
1-(1-Acetyl-3-piperidyl)-3-[[3-(2-phenoxyethoxy)phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-(1-Acetyl-3-piperidyl)-3-[[3-(2-morpholin-4-yl-2-oxo-ethoxy)phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-(1-Acetyl-3-piperidyl)-3-[[3-[2-oxo-2-(1-piperidyl)ethoxy]phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
2-[3-[[3-(1-Acetyl-3-piperidyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]methyl]phenoxy]-N-methyl-acetamide;
2-[3-[[3-(1-Acetyl-3-piperidyl)-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]methyl]phenoxy]-N-propan-2-yl-acetamide;
1-[1-(Benzenesulfonyl)-3-piperidyl]-5-phenyl-4-(piperazine-1-carbonyl)-3-prop-2-enyl-imidazol-2-one;
1-[1-(Benzenesulfonyl)-3-piperidyl]-3-(cyclohexylmethyl)-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-[1-(Benzenesulfonyl)-3-piperidyl]-3-[(3-phenoxyphenyl)methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-[(2-Amino1,3-thiazol-4-yl)methyl]-3-[1-(benzenesulfonyl)-3-piperidyl]-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
1-[1-(Benzenesulfonyl)-3-piperidyl]-3-[(3-methoxyphenyl)methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-[1-(Benzenesulfonyl)-3-piperidyl]-3-[(3,4-difluorophenyl)methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
N-[2-[3-[1-(Benzenesulfonyl)-3-piperidyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]benzamide;
N-[2-[3-[1-(Benzenesulfonyl)-3-piperidyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]benzenesulfonamide;
N-[2-[3-[1-(Benzenesulfonyl)-3-piperidyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]-3-methyl-butanamide;
N-[2-[3-[1-(Benzenesulfonyl)-3-piperidyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]-2-methyl-propane-1-sulfonamide;
N-[3-[3-[1-(Benzenesulfonyl)-3-piperidyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]benzamide;
N-[3-[3-[1-(Benzenesulfonyl)-3-piperidyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]benzenesulfonamide;
N-[3-[3-[1-(Benzenesulfonyl)-3-piperidyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]-3-methyl-butanamide;
N-[3-[3-[1-(Benzenesulfonyl)-3-piperidyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]-2-methyl-propane-1-sulfonamide;
1-[1-(Benzenesulfonyl)-3-piperidyl]-3-[[3-(2-methoxyethoxy)phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-[1-(Benzenesulfonyl)-3-piperidyl]-5-phenyl-4-(piperazine-1-carbonyl)-3-[[3-(2-pyridin-3-yloxyethoxy)phenyl]methyl]imidazol-2-one;
1-[1-(Benzenesulfonyl)-3-piperidyl]-5-phenyl-4-(piperazine-1-carbonyl)-3-[[3-(2-propan-2-yloxyethoxy)phenyl]methyl]imidazol-2-one;
1-[1-(Benzenesulfonyl)-3-piperidyl]-3-[[3-(2-phenoxyethoxy)phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-[1-(Benzenesulfonyl)-3-piperidyl]-3-[[3-(2-morpholin-4-yl-2-oxo-ethoxy)phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-[1-(Benzenesulfonyl)-3-piperidyl]-3-[[3-[2-oxo-2-(1-piperidyl)ethoxy]phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
2-[3-[[3-[1-(Benzenesulfonyl)-3-piperidyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]methyl]phenoxy]-N-methyl-acetamide;
2-[3-[[3-[1-(Benzenesulfonyl)-3-piperidyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]methyl]phenoxy]-N-propan-2-yl-acetamide;
N-[2-[2-oxo-5-Phenyl-4-(piperazine-1-carbonyl)-3-prop-2-enyl-imidazol-1-yl]phenyl]propane-1-sulfonamide;
N-[2-[3-(Cyclohexylmethyl)-2-oxo-5-phenyl-4-(piperazine-1-carbonyl)imidazol-1-yl]phenyl]propane-1-sulfonamide;
N-[2-[2-oxo-3-[(3-Phenoxyphenyl)methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-1-yl]phenyl]propane-1-sulfonamide;
N-[2-[3-[(2-Amino1,3-thiazol-4-yl)methyl]-2-oxo-5-phenyl-4-(piperazine-1-carbonyl)imidazol-1-yl]phenyl]propane-1-sulfonamide;
N-[2-[3-[(3-Methoxyphenyl)methyl]-2-oxo-5-phenyl-4-(piperazine-1-carbonyl)imidazol-1-yl]phenyl]propane-1-sulfonamide;
N-[2-[3-[(3,4-Difluorophenyl)methyl]-2-oxo-5-phenyl-4-(piperazine-1-carbonyl)imidazol-1-yl]phenyl]propane-1-sulfonamide;
N-[2-[2-oxo-4-Phenyl-5-(piperazine-1-carbonyl)-3-[2-(propylsulfonylamino)phenyl]imidazol-1-yl]ethyl]benzamide;
N-[2-[2-oxo-4-Phenyl-5-(piperazine-1-carbonyl)-3-[2-(propylsulfonylamino)phenyl]imidazol-1-yl]ethyl]benzenesulfonamide;
3-Methyl-N-[2-[2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-[2-(propylsulfonylamino)phenyl]imidazol-1-yl]ethyl]butanamide;
2-Methyl-N-[2-[2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-[2-(propylsulfonylamino)phenyl]imidazol-1-yl]ethyl]propane-1-sulfonamide;
N-[3-[2-oxo-4-Phenyl-5-(piperazine-1-carbonyl)-3-[2-(propylsulfonylamino)phenyl]imidazol-1-yl]propyl]benzamide;
N-[3-[2-oxo-4-Phenyl-5-(piperazine-1-carbonyl)-3-[2-(propylsulfonylamino)phenyl]imidazol-1-yl]propyl]benzenesulfonamide;
3-Methyl-N-[3-[2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-[2-(propylsulfonylamino)phenyl]imidazol-1-yl]propyl]butanamide;
2-Methyl-N-[3-[2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-[2-(propylsulfonylamino)phenyl]imidazol-1-yl]propyl]propane-1-sulfonamide;
N-[2-[3-[[3-(2-Methoxyethoxy)phenyl]methyl]-2-oxo-5-phenyl-4-(piperazine-1-carbonyl)imidazol-1-yl]phenyl]propane-1-sulfonamide;
N-[2-[2-oxo-5-Phenyl-4-(piperazine-1-carbonyl)-3-[[3-(2-pyridin-3-yloxyethoxy)phenyl]methyl]imidazol-1-yl]phenyl]propane-1-sulfonamide;
N-[2-[2-oxo-5-Phenyl-4-(piperazine-1-carbonyl)-3-[[3-(2-propan-2-yloxyethoxy)phenyl]methyl]imidazol-1-yl]phenyl]propane-1-sulfonamide;
N-[2-[2-oxo-3-[[3-(2-Phenoxyethoxy)phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-1-yl]phenyl]propane-1-sulfonamide;
N-[2-[3-[[3-(2-Morpholin-4-yl-2-oxo-ethoxy)phenyl]methyl]-2-oxo-5-phenyl-4-(piperazine-1-carbonyl)imidazol-1-yl]phenyl]propane-1-sulfonamide;
N-[2-[2-oxo-3-[[3-[2-oxo-2-(1-Piperidyl)ethoxy]phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-1-yl]phenyl]propane-1-sulfonamide;
N-Methyl-2-[3-[[2-oxo-4-phenyl-5-(piperazine-1-carbonyl)-3-[2-(propylsulfonylamino)phenyl]imidazol-1-yl]methyl]phenoxy]acetamide;
2-[3-[[2-oxo-4-Phenyl-5-(piperazine-1-carbonyl)-3-[2-(propylsulfonylamino)phenyl]imidazol-1-yl]methyl]phenoxy]-N-propan-2-yl-acetamide;
1-[1-(1-Methylpyrazol-4-yl)sulfonyl-3-piperidyl]-5-phenyl-4-(piperazine-1-carbonyl)-3-prop-2-enyl-imidazol-2-one;
1-(Cyclohexylmethyl)-3-[1-(1-methylpyrazol-4-yl)sulfonyl-3-piperidyl]-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
1-[1-(1-Methylpyrazol-4-yl)sulfonyl-3-piperidyl]-3-[(3-phenoxyphenyl)methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-[(2-Amino1,3-thiazol-4-yl)methyl]-3-[1-(1-methylpyrazol-4-yl)sulfonyl-3-piperidyl]-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
1-[(3-Methoxyphenyl)methyl]-3-[1-(1-methylpyrazol-4-yl)sulfonyl-3-piperidyl]-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
1-[(3,4-Difluorophenyl)methyl]-3-[1-(1-methylpyrazol-4-yl)sulfonyl-3-piperidyl]-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
N-[2-[3-[1-(1-Methylpyrazol-4-yl)sulfonyl-3-piperidyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]benzamide;
N-[2-[3-[1-(1-Methylpyrazol-4-yl)sulfonyl-3-piperidyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]benzenesulfonamide;
3-Methyl-N-[2-[3-[1-(1-methylpyrazol-4-yl)sulfonyl-3-piperidyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]butanamide;
2-Methyl-N-[2-[3-[1-(1-methylpyrazol-4-yl)sulfonyl-3-piperidyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]propane-1-sulfonamide;
N-[3-[3-[1-(1-Methylpyrazol-4-yl)sulfonyl-3-piperidyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]benzamide;
N-[3-[3-[1-(1-Methylpyrazol-4-yl)sulfonyl-3-piperidyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]benzenesulfonamide;
3-Methyl-N-[3-[3-[1-(1-methylpyrazol-4-yl)sulfonyl-3-piperidyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]butanamide;
2-Methyl-N-[3-[3-[1-(1-methylpyrazol-4-yl)sulfonyl-3-piperidyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]propane-1-sulfonamide;
1-[[3-(2-Methoxyethoxy)phenyl]methyl]-3-[1-(1-methylpyrazol-4-yl)sulfonyl-3-piperidyl]-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
1-[1-(1-Methylpyrazol-4-yl)sulfonyl-3-piperidyl]-5-phenyl-4-(piperazine-1-carbonyl)-3-[[3-(2-pyridin-3-yloxyethoxy)phenyl]methyl]imidazol-2-one;
1-[1-(1-Methylpyrazol-4-yl)sulfonyl-3-piperidyl]-5-phenyl-4-(piperazine-1-carbonyl)-3-[[3-(2-propan-2-yloxyethoxy)phenyl]methyl]imidazol-2-one;
1-[1-(1-Methylpyrazol-4-yl)sulfonyl-3-piperidyl]-3-[[3-(2-phenoxyethoxy)phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-[1-(1-Methylpyrazol-4-yl)sulfonyl-3-piperidyl]-3-[[3-(2-morpholin-4-yl-2-oxo-ethoxy)phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-[1-(1-Methylpyrazol-4-yl)sulfonyl-3-piperidyl]-3-[[3-[2-oxo-2-(1-piperidyl)ethoxy]phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
N-Methyl-2-[3-[[3-[1-(1-methylpyrazol-4-yl)sulfonyl-3-piperidyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]methyl]phenoxy]acetamide;
2-[3-[[3-[1-(1-Methylpyrazol-4-yl)sulfonyl-3-piperidyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]methyl]phenoxy]-N-propan-2-yl-acetamide;
1-[(2R)-2-Hydroxycyclohexyl]-5-phenyl-4-(piperazine-1-carbonyl)-3-prop-2-enyl-imidazol-2-one;
1-(Cyclohexylmethyl)-3-[(2R)-2-hydroxycyclohexyl]-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
1-[(2R)-2-Hydroxycyclohexyl]-3-[(3-phenoxyphenyl)methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-[(2-Amino1,3-thiazol-4-yl)methyl]-3-[(2R)-2-hydroxycyclohexyl]-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
1-[(2R)-2-Hydroxycyclohexyl]-3-[(3-methoxyphenyl)methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-[(3,4-Difluorophenyl)methyl]-3-[(2R)-2-hydroxycyclohexyl]-4-phenyl-5-(piperazine-1-carbonyl)imidazol-2-one;
N-[2-[3-[(2R)-2-Hydroxycyclohexyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]benzamide;
N-[2-[3-[(2R)-2-Hydroxycyclohexyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]benzenesulfonamide;
N-[2-[3-[(2R)-2-Hydroxycyclohexyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]-3-methyl-butanamide;
N-[2-[3-[(2R)-2-Hydroxycyclohexyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]ethyl]-2-methyl-propane-1-sulfonamide;
N-[3-[3-[(2R)-2-Hydroxycyclohexyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]benzamide;
N-[3-[3-[(2R)-2-Hydroxycyclohexyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]benzenesulfonamide;
N-[3-[3-[(2R)-2-Hydroxycyclohexyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]-3-methyl-butanamide;
N-[3-[3-[(2R)-2-Hydroxycyclohexyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]propyl]-2-methyl-propane-1-sulfonamide;
1-[(2R)-2-Hydroxycyclohexyl]-3-[[3-(2-methoxyethoxy)phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-[(2R)-2-Hydroxycyclohexyl]-5-phenyl-4-(piperazine-1-carbonyl)-3-[[3-(2-pyridin-3-yloxyethoxy)phenyl]methyl]imidazol-2-one;
1-[(2R)-2-Hydroxycyclohexyl]-5-phenyl-4-(piperazine-1-carbonyl)-3-[[3-(2-propan-2-yloxyethoxy)phenyl]methyl]imidazol-2-one;
1-[(2R)-2-Hydroxycyclohexyl]-3-[[3-(2-phenoxyethoxy)phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-[(2R)-2-Hydroxycyclohexyl]-3-[[3-(2-morpholin-4-yl-2-oxo-ethoxy)phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
1-[(2R)-2-Hydroxycyclohexyl]-3-[[3-[2-oxo-2-(1-piperidyl)ethoxy]phenyl]methyl]-5-phenyl-4-(piperazine-1-carbonyl)imidazol-2-one;
2-[3-[[3-[(2R)-2-Hydroxycyclohexyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]methyl]phenoxy]-N-methyl-acetamide;
2-[3-[[3-[(2R)-2-Hydroxycyclohexyl]-2-oxo-4-phenyl-5-(piperazine-1-carbonyl)imidazol-1-yl]methyl]phenoxy]-N-propan-2-yl-acetamide;
(R)-Ethyl 6-(4-(2-benzylpiperazine-1-carbonyl)-2-oxo-5-phenyl-2,3-dihydro-1H-imidazol-1-yl)indoline-1-carboxylate; and
a pharmaceutically acceptable salt of any one of the aforementioned compounds.

### Claim 12 (depends on 1)

A pharmaceutical composition comprising a compound as defined in claim 1 and a pharmaceutically acceptable excipient.

### Claim 13 (depends on 1)

A method of treating a disease in a subject, the method comprising administering a compound as defined in claim 1 to the subject having the disease, wherein the disease is hypertension.