# US 8,147,848 B2 · Method for treating premature ejaculation with a botulinum neurotoxin

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- Number: US 8,147,848 B2
- Document ID: US8147848B2
- Status: Granted
- Kind: B2
- Application number: 12/548,073
- Filed: 2009-08-26
- Published: 2011-03-03
- Granted: 2012-04-03
- Earliest claimed: 2009-08-26
- Assignees: Allergan, Inc.
- Inventors: Gustavo M. Gaxiola; Ivan E. Aguilar; Gilberto P. Paz
- Web page: https://patentgrep.com/patent/US8147848B2

## CPC

- A61K 38/4893: {Botulinum neurotoxin (3.4.24.69)}
- A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)}
- A61K 9/0034: {Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants}
- A61P 15/00: Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives
- A61P 15/08: for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A61P 15/10: for impotence
- A61P 15/12: for climacteric disorders
- C12Y 304/24069: Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C12Y: ENZYMES

## Abstract

Methods for prolongation of climax time in a patient in need thereof are presented, as are methods for treating premature ejaculation by local administration of a Clostridial neurotoxin, such a botulinum neurotoxin, to the patient, are provided.

## Claims

### Claim 1

A method for treating premature ejaculation in a patient in need thereof, the method comprising the step of locally administering by injection a botulinum neurotoxin to a penis of the patient, thereby treating premature ejaculation in the patient, wherein said local administration is to a frenulum of the penis.

### Claim 2 (depends on 1)

The method of claim 1, wherein the botulinum neurotoxin is a botulinum neurotoxin type B and the botulinum neurotoxin type B is administered in an amount between 1 unit and about 10,000 units.

### Claim 3

A method for treating premature ejaculation in a patient in need thereof, the method comprising the step of locally administering a botulinum neurotoxin type A to at least one location of a penis of the patient, thereby treating premature ejaculation in the patient, wherein the botulinum neurotoxin is administered to a prepuce a frenulum or glans of the penis, and further wherein an amount of botulinum neurotoxin type A administered to the penis is from about 1 unit to about 2500 units.

### Claim 4 (depends on 3)

The method of claim 3, wherein the botulinum neurotoxin type A is administered to a prepuce of the penis.

### Claim 5 (depends on 3)

The method of claim 3, wherein local administration of the botulinum neurotoxin is to a frenulum or prepuce.