Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions
AssigneeOncolytics Biotech Inc.
InventorsDonald Morris, Bradley G. Thompson, Matthew C. Coffey
Life of this patent
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Abstract
Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.
Claims24
A method of removing neoplastic cells from a cellular composition for transplantation comprising contacting, prior to transplantation, the cellular composition with one or more reoviruses under conditions that result in lysis of the neoplastic cells.
Dependencies are inferred from the claim text.