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US 8,138,383 B2Granted
Membrane active heteropolymers
AssigneeArrowhead Madison Inc.
InventorsDarren H. Wakefield, David B. Rozema, Jon A. Wolff, James E. Hagstrom
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Abstract
The present invention is directed to a class of membrane active polymers useful for cellular delivery of compounds. Conjugation of the described membrane active polymers to targeting, anti-opsonization, and anti-aggregation agents provides polymers suitable for in vivo delivery. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
Claims16
A membrane active amine-containing random copolymer, wherein said polymer comprises:
- plurality of first monomers each containing a pendant primary amine group, a plurality of second monomers each containing a pendant linear alkyl group having two to four carbon atoms, and a plurality of third monomers each containing a pendant linear alkyl group having eight or more carbon atoms wherein said random copolymer is capable of lysing red blood cells.
Dependencies are inferred from the claim text.