Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
AssigneeDOV Pharmaceutical, Inc.
InventorsPhil Skolnick, Zhengming Chen, Ji Yang
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Abstract
The invention provides novel arylbicyclo[3.1.0]hexylamines, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including but not limited to depression and anxiety.
Claims2
A method for treating a central nervous system (CNS) disorder selected from the group consisting of depression, an anxiety disorder, an attention deficit disorder, substance abuse, and an eating disorder in a mammalian subject comprising administering to said subject an effective amount of a compound sufficient to treat said CNS disorder, or to alleviate the CNS disorder wherein the compound is 1-p-tolylbicyclo[3.1.0]hexan-2-amine;
- N-methyl-1-p-tolylbicyclo[3.1.0]hexan-2-amine;
- N,N-dimethyl-1-p-tolylbicyclo[3.1.0]hexan-2-amine;
- 1-(3,4-dichlorophenyl)bicyclo[3.1.0]hexan-2-amine;
- 1-(3,4-dichlorophenyl)-N-methylbicyclo[3.1.0]hexan-2-amine;
- 1-(3,4-dichlorophenyl)-N,N-dimethylbicyclo[3.1.0]hexan-2-amine;
- 1-p-tolylbicyclo[3.1.0]hexan-3-amine;
- N-methyl-1-p-tolylbicyclo[3.1.0]hexan-3-amine;
- N,N-dimethyl-1 -p-tolylbicyclo[3.1.0]hexan-3-amine;
- 1-(3,4-dichlorophenyl)bicyclo[3.1.0]hexan-3-amine;
- 1-(3,4-dichlorophenyl)-N-methylbicyclo[3.1.0]hexan-3-amine;
- 1-(3,4-dichlorophenyl)-N,N-dimethylbicyclo[3.1.0]hexan-3-amine;
- 5-p-tolylbicyclo[3.1.0]hexan-2-amine;
- N-methyl-5-p-tolylbicyclo [3.1.0]hexan-2-amine;
- N,N-dimethyl-5-p-tolylbicyclo[3.1.0]hexan-2-amine;
- 5-(3,4-dichlorophenyl)bicyclo[3.1.0]hexan-2-amine;
- 5-(3,4-dichlorophenyl)-N-methylbicyclo[3.1.0]hexan-2-amine;
- and 5-(3,4-dichlorophenyl)-N,N-dimethylbicyclo[3.1.0]hexan-2-amine, N-methyl-1-(naphthalen- 1-yl)bicyclo[3.1.0]hexan-3-amine;
- N,N-dimethyl-1-(naphthalen-1-yl)bicyclo[3.1.0]hexan-3-amine;
- N-methyl-1-(naphthalen-2-yl) bicyclo[3.1.0]hexan-3-amine;
- N-methyl-5-(naphthalen-1-yl)bicyclo[3.1.0]hexan-2-amine;
- N,N-dimethyl-5-(naphthalen-1-yl)bicyclo[3.1.0]hexan-2-amine;
- N-methyl-5-(naphthalen-2-yl)bicyclo[3.1.0]hexan-2-amine;
- and N,N-dimethyl-5-(naphthalen-2-yl)bicyclo[3.1.0]hexan-2-amine, or pharmaceutically acceptable salts, enantiomers, hydrates, and combinations thereof.
Dependencies are inferred from the claim text.