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US 8,138,370 B2Granted
Method of producing optically active α-amino acid benzyl esters
AssigneeSumitomo Chemical Company, Limited
InventorNorihiko Hirata
Life of this patent
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Abstract
A method is provided for producing optically active α-amino acid benzyl esters. The method includes reacting an optically active α-amino acid and benzyl alcohols in the presence of an acid, wherein the reaction is carried out under reduced pressure without substantially using a solvent, while distilling off water generated by the progress of the reaction.
Claims11
A method of producing optically active α-amino acid benzyl esters comprising reacting an optically active α-amino acid and benzyl alcohols of the formula (1):
- wherein R1 and R2 are mutually the same or different and represent a hydrogen atom, alkyl group having 1 to 6 carbon atoms, alkoxy group having 1 to 6 carbon atoms, nitro group, cyano group or halogen atom in the presence of an acid, wherein the reaction is carried out at a reaction temperature within a of 40 to 70° C. under reduced pressure without using a solvent, while distilling off water generated by the progress of the reaction.
Dependencies are inferred from the claim text.