C-10 carbamates of taxanes

A compound of formula 1:

• or pharmaceutically acceptable compound, wherein
• R1 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl or acyl;
• R2 is alkyl or aryl, wherein the aryl group is optionally substituted with one to three electron withdrawing or electron donating groups;
• R7 is H or OR7a where R7a is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —COR7b, —CONR7cR7d or is hydroxyl protecting group, wherein
• R7b is alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, and
• R7c and R7b are each independently selected as follows:
• a) R7c and R7d are each independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, or
• b) R7c and R7d together with the nitrogen atom form an optionally substituted 5-7 membered heterocyclic or heteroaryl ring;
• R9 is ═O, or —OR7a;
• X is NRxRy, where Rx is hydrogen or alkyl and Ry is carboxyalkyl, carboxyheteroalkyl, carboxyalkenyl, carboxyalkynyl, carboxycycloalkyl, carboxyheterocyclyl, carboxyaryl, carboxyheteroaryl or aminoheteroalkyl,
• wherein the amino group is optionally protected with a protecting group;
• R14 is hydrogen, hydroxyl or alkoxy;
• R3a is alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl or heteroaryl;
• R4a is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl or is hydroxyl protecting group;
• R5a is —COR7b, —COOR7b, or CONR7cR7d;
• and
• R1, R2, R3a, R4a, R5a, R7a, R7b, R7c, R7d, Ry, and R14 are unsubstituted or substituted with 1-4 substituents Q1, wherein each Q1 is independently halo, pseudohalo, hydroxy, oxo, thia, nitrile, amino, nitro, formyl, mercapto, hydroxycarbonyl, hydroxycarbonylalkyl, alkyl, haloalkyl, aminoalkyl, diaminoalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycclylalkyl, aryl, heteroaryl, aralkyl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, alkoxycarbonyl, aralkyloxycarbonyl, aralkoxycarbonylamino, aminocarbonyl, alkoxy, aryloxy, heteroaryloxy, heteroaralkoxy, heterocyclyloxy, cycloalkoxy, aralkoxy, alkylamino, dialkylamino, haloalkylamino, arylamino, diarylamino or alkylarylamino
• with the proviso that when R1 is hydrogen, R2 is aryl, R3a is aryl, R4a is hydrogen, R5a is —COR7b, R7b is aryl, R7 is —OH, and R9 is ═O, X is NRxRy, and Rx is hydrogen, then Ry is not aminoheteroalkyl.