Isotopically-labeled benzofuran compounds as imaging agents for amyloidogenic proteins

An amyloid binding compound of Formula (I) or a pharmaceutically acceptable salt thereof:

• wherein
• Y is H, NO2, F, Cl, Br, I, O—(CR″2)n—X, or —(CR″2)n-X;
• wherein
• X is F, Cl, Br or I;
• and
• n is 1-5;
• R′ is H or a lower alkyl group;
• R″ is H or a lower alkyl group;
• R3-R10 are independently selected from the group consisting of H, F, Cl, Br, I, C1-C5 alkyl, (CH2)1-3—OR11, CF3, —(CH2)1-3—X, —O—(CH2)1-3—X, CN, —CO—R11, —N(R11)2, —NR″3+, —NO2, —CO—N(R11)2, —O—(CO)—R11, OR11, SR11, COOR11, Rph, —CR11═CR11—Rph and —C(R11)2—C(R11)2—Rph,
• wherein one or both of R8 and R9 are independently OR11,
• and wherein
• X is F, Cl, Br or I;
• and
• Rph is phenyl optionally substituted with one or more substituents selected from the group consisting of F, Cl, Br, I, C1-C5 alkyl, (CH2)1-3-OR11, CF3, —(CH2)1-3—X, —O —(CH2)1-3—X, CN, —CO—R11, —N(R11)2, —CO—N(R11)2, —O—(CO)—R11, OR11, SR11, and COOR11, wherein each R11 is independently H or C1-C5 alkyl;
• and
• Y or R3-R10 comprises at least one detectable label selected from the group consisting of 131I, 123I, 124I, 125I, 76Br, 75Br, 18F, 19F, 11C, 13C, 14C and 3H.