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US 8,138,353 B2Granted
Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors
AssigneeGenzyme Corporation
InventorsBradford H. Hirth, Craig Siegel
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Abstract
Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
Claims6
A compound represented by the following structural formula:
- the enantiomer of the compound, a salt of the compound, or a salt of the enantiomer, wherein:
- R1 is a substituted or unsubstituted aromatic group;
- R2 and R3 are independently —H, a substituted or unsubstituted aliphatic group or, taken together with the nitrogen atom to which they are bonded, are a substituted or unsubstituted non-aromatic heterocyclic ring;
- R4 is O or H2;
- and
- R5 is a substituted or unsubstituted aromatic group.
3 more elements
A compound represented by the following structural formula:
- the enantiomer of the compound, a salt of the compound, or a salt of the enantiomer, wherein R1 is a substituted or unsubstituted phenyl group and R4 is H2 or O.
Dependencies are inferred from the claim text.