Method for producing asymmetric tetrasubstituted carbon atom-containing compound
AssigneeDaiichi Sankyo Company, Limited
InventorsYuichiro Tani, Yutaka Kitagawa, Makoto Muto, Toshiaki Jyono
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Abstract
The invention provides an industrial method for producing a spiroaminopyrrolidone derivative, which is an intermediate for producing a quinolone antibacterial agent. Specifically, the invention provides a method for producing a compound of formula (2): wherein n is an integer of 2 to 5; R1 is a (substituted) alkyl group or a (substituted) aryl group; and R2 represents a (substituted) alkoxycarbonyl group, a (substituted) aralkyloxycarbonyl group, a (substituted) aliphatic acyl group, or a (substituted) aromatic acyl group).
Claims5
A method for producing a compound of formula (2):
- wherein n is an integer of 2 to 5;
- R1 is a C1 to C4 alkyl group which may have a substituent or an aryl group which may have a substituent;
- and
- R2 is an alkoxycarbonyl group which may have a substituent, an aralkyloxycarbonyl group which may have a substituent, an aliphatic acyl group which may have a substituent, or an aromatic acyl group which may have a substituent,
- said method comprising
- treating a compound of formula (1):
- wherein n, R1, and R2 are the same as defined above;
- and
- R3 is a C1 to C4 alkyl group which may have a substituent, an aralkyl group which may have a substituent, or a hydrogen atom
- under a hydrogen gas atmosphere in the presence of a metallic catalyst.
Dependencies are inferred from the claim text.