Diamide compounds having muscarinic receptor antagonist and β2 adrenergic receptor agonist activity
AssigneeTheravance, Inc.
InventorsAdam Hughes, Daniel Byun, Yan Chen, Melissa Fleury, John R. Jacobsen, Eric L. Stangeland, Richard D. Wilson, Rose Yen
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Abstract
This invention relates to a compound of formula I: or a pharmaceutically acceptable salt thereof. Such compounds possess both muscarinic receptor antagonist and β2 adrenergic receptor agonist activities. The invention also relates to pharmaceutical compositions comprising such compounds, processes and intermediates for preparing such compounds, and methods of using such compounds as bronchodilating agents to treat pulmonary disorders.
Claims3
Biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester of formula:
- or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising
- (a) biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}phenylcarbamoyl)butyl]methylcarbamoyl}-ethyl)piperidin-4-yl ester of formula:
- or a pharmaceutically acceptable salt thereof;
- and
- (b) a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising
- (a) biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}phenylcarbamoyl)butyl]methylcarbamoyl}-ethyl)piperidin-4-yl ester of formula:
- or a pharmaceutically acceptable salt thereof;
- (b) a steroidal anti-inflammatory agent or a pharmaceutically acceptable salt or solvate thereof;
- and
- (c) a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.