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US 8,138,343 B2Granted
Crystalline polymorph of 7-ethyl-10-hydroxycamptothecin
AssigneeScinoPharm Taiwan, Ltd.
InventorsShu-Ping Chen, Piin-Jye Harn
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Abstract
A crystalline polymorph of 7-ethyl-10-hydroxycamptothecin exhibiting an X-ray diffraction pattern having peaks at 10.9±0.2, 13.2±0.2, 23.9±0.2, and 26.1±0.2 2-theta degree.
Claims13
A crystalline polymorph of 7-ethyl-10-hydroxycamptothecin exhibiting an X-ray diffraction pattern having peaks at 10.9±0.2, 13.2±0.2, 23.9±0.2, and 26.1±0.2 2-theta degree.
A process of making crystalline 7-ethyl-10-hydroxycamptothecin comprising:
- (1) dissolving crude 7-ethyl-10-hydroxycamptothecin with a solvent selected from the group consisting of acetic acid, dimethyl sulfoxide, N,N-dimethylacetamide and mixtures thereof to form a solution;
- (2) forming crystals of 7-ethyl-10-hydroxycamptothecin by adding an antisolvent selected from the group consisting of 1,2-dichloroethane, acetone, ethyl acetate, ethanol, and mixtures thereof to the solution of step 1) to obtain a slurry;
- (3) filtering the slurry of step (2) to obtain the crystalline solid 7-ethyl-10-hydroxycamptothecin.
Dependencies are inferred from the claim text.