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US 8,138,342 B2Granted
11β-hydroxysteroid dehydrogenase type 1 active spiro compounds
AssigneeHigh Point Pharmacueticals, LLC
InventorsJohn Paul Kilburn, Henrik Sune Andersen, Gita Camilla Tejlgaard Kampen
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Abstract
A novel class of compounds of the general formula (I), their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds modulate the activity of 11 β-hydroxy-Steroid dehydrogenase type 1 (11βHSD1) and are accordingly useful in the treatment of diseases in which such a modulation is beneficial, e.g. the metabolic syndrome.
Claims2
A compound selected from the group consisting of:
- 2,3-Dihydrospiro(1-methanesulfonyl-indol-3,4′-piperidin-1-yl)-(1H-indol-5-yl)-methanone;
- 2,3-Dihydrospiro(1-methanesulfonyl-indol-3,4′-piperidin-1-yl)-(3-N,N-dimethylamino-phenyl)-methanone;
- and
- 2,3-Dihydrospiro(1-methanesulfonyl-indol-3,4′-piperidin-1-yl)-(benzimidazol-5-yl)-methanone;
- or
- a pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.