Inhibitors of protein kinases

A compound having the formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• D1 is C3-8cycloalkyl, optionally substituted with from 1 to 4 substituents independently selected from the group consisting of:
• C1-8 alkyl, amino, hydroxy, C1-8alkylcarbonyl, aminocarbonyl, C1-8alkoxycarbonylamino, arylC1-8alkoxycarbonylamino, phenyl and heterocyclylC1-8alkylene;
• wherein the cycloalkyl does not have more than one double bond;
• R1 is selected from the group consisting of H, C1-8 alkyl, amino, aminocarbonyl, hydroxyl, C1-8 alkoxy, C1-8 haloalkyl, C2-8 alkenyl, C2-8 alkynyl, oxo, cyano, C1-8 alkoxycarbonyl, C3-8 cycloalkyl, aryl and heterocyclyl;
• and each heterocyclyl is optionally substituted with from 1 to 4 substituents selected from the group consisting of:
• C1-8 alkyl, halo, oxo, amino, C1-8alkoxy, C1-8alkylcarbonyl, arylC1-8 alkoxycarbonyl, aminocarbonyl, arylC1-8 alkylenecarbonyl and C1-8 alkylsulfonyl
• Y1 is aryl;
• optionally substituted with from 1 to 3 substituents, R4a, independently selected from the group consisting of C1-8alkyl, C1-8alkoxyC1-8alkyl, aminocarbonyl-, hydroxyl, oxo, halogen, hydroxy, C1-8alkoxy and C1-8alkylsulfonyl;
• R2 is selected from the group consisting of heterocyclyl and heteroaryl, each of which is substituted with at least one group, R3, selected from the group consisting of aminoC1-8alkyl-, C1-8alkoxyC1-8alkyl-, oxo-, C1-8alkylcarbonyl, C3-8cycloalkylcarbonyl, heterocyclylcarbonyl, C1-8alkylcarbonylamino, C3-8cycloalkylcarbonylamino, heterocyclylcarbonylamino, aminosulfonyl, C1-8alkylsulfonyl, C3-8cycloalkylsulfonyl and heterocyclylsulfonyl;
• and wherein R2 is further optionally substituted with from 1 to 2 substituents, R4c, independently selected from the group consisting of C1-8 alkyl, C1-8alkoxy, halo, aminocarbonyl, oxo, hydroxyl, aminoC1-8alkylene, C1-8alkoxyC1-8alkylene, C1-8alkylcarbonyl, C3-8cycloalkylcarbonyl, heterocyclylcarbonyl, C1-8alkylcarbonylamino, C3-8cycloalkylcarbonylamino, heterocyclylcarbonylamino, C1-8alkylsulfonyl, C3-8cycloalkylsulfonyl, heterocyclylsulfonyl, C3-8cycloalkyl, C1-8alkylcycloalkylene, and heteroaryl.