US 8,138,335 B2 · Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient

Abstract

A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g., scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis, etc. Since it specifically binds to DP receptor and binds weakly to other prostaglandins receptors, they can be pharmaceuticals having little side effect.

A method for treatment of allergic diseases, which comprises administering to a mammal an effective amount of the compound

represented by formula (I)
wherein R1 represents (1) a hydrogen atom, (2) C1-4 alkyl, (3) C2-4 alkenyl, or (4) benzyl;
E represents —CO— or —SO2—;
R2 represents (1) a halogen atom, (2) C1-6 alkyl, (3) C1-6 alkoxy, (4) hydroxyl, (5) trihalomethyl, (6) cyano, (7) phenyl, (8) pyridyl, (9) nitro, (10) —NR6R7, or (11) C1-4 alkyl substituted with —OR8, (12) oxidized C1-6 alkyl, (13) —SO2R11, (14) —SOR11, or (15) —SR11, or two R2's substituting for the adjacent carbon atom are taken together to represent (1) C2-5 alkylene which may be substituted by a substituent wherein one carbon atom thereof may be replaced with an oxygen atom, a nitrogen atom, or a sulfur atom which may be oxidized, or (2) C2-5 alkenylene which may be substituted by a substituent, wherein one carbon atom thereof may be replaced with an oxygen atom, a nitrogen atom, or a sulfur atom;
R3 represents (1) a halogen atom, (2) C1-6 alkyl, (3) C1-6 alkoxy, (4) hydroxyl, (5) trihalomethyl, (6) cyano, (7) phenyl, (8) pyridyl, (9) nitro, (10) —NR6R7 or (11) C1-4 alkyl substituted with —OR8, (12) oxidized C1-6 alkyl, (13) —SO2R11, (14) —SOR11, or (15) —SR11;
R6 and R7 each independently represent a hydrogen atom or C1-4 alkyl;
R8 represents C1-4 alkyl, phenyl, or pyridyl;
R4 represents (1) a hydrogen atom, (2) C1-6 alkyl, (3) benzyl, or (4) oxidized C1-6 alkyl;
R5 represents (1) C1-6 alkyl, (2) C1-10 alkoxy, (3) C1-6 alkyl substituted with C1-6 alkoxy, (4) a halogen atom, (5) hydroxyl, (6) trihalomethyl, (7) nitro, (8) —NR9R10, (9) phenyl, (10) phenoxy, (11) oxo, (12) C2-6 acyl, (13) cyano or (14) —SO2R11, (15) —SOR11, (16) —SR11, (12) oxidized C1-6 alkyl;
R9 and R10 each independently represent a hydrogen atom or C1-4 alkyl;
and
R11 represents C1-6 alkyl or phenyl which may be substituted;
wherein R6's to R11's in R2's to R5's may be the same or each independently different;
represents a C5-12 monocyclic or bicyclic carbocyclic ring or a 5- to 12-membered monocyclic or bicyclic heterocycle;
G represents (1) C1-6 alkylene having 0 to 2 hetero atoms selected from a nitrogen atom, an oxygen atom, and a sulfur atom, (2) C2-6 alkenylene having 0 to 2 hetero atoms selected from a nitrogen atom, an oxygen atom, and a sulfur atom, or (3) C2-6 alkynylene having 0 to 2 hetero atoms selected from a nitrogen atom, an oxygen atom, and a sulfur atom;
represents a C5-12 monocyclic or bicyclic carbocyclic ring or a 5- to 12-membered monocyclic or bicyclic heterocycle;
m represents 0 or an integer of 1 to 4,
n represents 0 or an integer of 1 to 4, and
represents 0 or an integer of 1 to 11,
wherein R2's may be the same or different when m is 2 or more, R3's may be the same or different when n is 2 or more, and R5's may be the same or different when i is 2 or more;
and
R12 and R13 each independently represent (1) C1-4 alkyl which may be oxidized, (2) a halogen atom, (3) trihalomethyl, (4) hydroxyl which may be protected, (5) amino which may be protected, (6) phenyl which may be substituted, (7) pyridyl which may be substituted, or (8) a hydrogen atom, or R12 and R13 are taken together to represent (1) oxo, (2) C2-5 alkylene which may be substituted by a substituent, wherein one carbon atom thereof may be replaced with an oxygen atom, a nitrogen atom, or a sulfur atom, or (3) C1-6 alkylidene which may be substituted, and
wherein when R12 and R13 each simultaneously represent a hydrogen atom, the carboxylic acid compound represented by formula (I) represents a compound selected from the group consisting of the following compounds (1)-(32);
(1) (3-((2,3-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)-4-fluorophenyl)acetic acid,
(2) (4-chloro-3-((2,3-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)phenyl)acetic acid,
(3) (4-chloro-3-((2,6-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)phenyl)acetic acid,
(4) (4-chloro-3-((5-chloro-2-fluoro-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)phenyl)acetic acid,
(5) (4-chloro-3-((2,5-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)phenyl)acetic acid,
(6) (4-chloro-3-((2-fluoro-5-methyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)phenyl)acetic acid,
(7) (4-chloro-3-((2,5-difluoro-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)phenyl)acetic acid,
(8) (3-((2,3-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)-4-methylphenyl)acetic acid,
(9) (3-((2,3-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)-5-methylphenyl)acetic acid,
(10) (3-((2,3-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)phenyl)acetic acid,
(11) (3-((2,6-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)phenyl)acetic acid,
(12) (3-((2,6-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)-5-methylphenyl)acetic acid,
(13) (5-((2,6-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)-2-fluorophenyl)acetic acid,
(14) (5-((2,5-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)-2-methylphenyl)acetic acid,
(15) (5-((2,5-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)-2-fluorophenyl)acetic acid,
(16) (3-((2,5-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)phenyl)acetic acid,
(17) (5-((2,3-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)-2-fluorophenyl)acetic acid,
(18) (5-((2,3-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)-2-methylphenyl)acetic acid,
(19) (5-((2,6-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)-2-methylphenyl)acetic acid,
(20) (3-((2,6-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)-4-methylphenyl)acetic acid,
(21) (3-((2,6-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)-4-fluorophenyl)acetic acid,
(22) (3-((2,5-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)-4-fluorophenyl)acetic acid,
(23) (3-((2,5-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)-4-methylphenyl)acetic acid,
(24) (3-((2,5-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)-5-methylphenyl)acetic acid,
(25) (4-chloro-3-((4-((2R)-2,3-dihydro-1,4-benzodioxin-2-lymethoxy)-2,6-dimethylbenzoyl)amino)phenyl)acetic acid,
(26) (2-chloro-5-((2,3-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)phenyl)acetic acid,
(27) (2-chloro-5-((2,6-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)phenyl)acetic acid,
(28) (2-chloro-5-((2,5-dimethyl-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)phenyl)acetic acid,
(29) (4-chloro-3-((4-((3R)-2,3-dihydro-1-benzofuran-3-lymethoxy)-2,6-dimethylbenzoyl)amino)phenyl)acetic acid,
(30) (4-chloro-3-((2,6-dimethyl-4-(((3R)-5-methyl-2,3-dihydro-1-benzofuran-3-yl)methoxy)benzoyl)amino)phenyl)acetic acid,
(31) (4-chloro-3-((4-((2S)-2,3-dihydro-1-benzofuran-2-lymethoxy)-2,6-dimethylbenzoyl)amino)phenyl)acetic acid, and
(32) (3-((4-(1,3-benzodioxol-2-lymethoxy)-2,6-dimethylbenzoylamino)-4-chlorophenyl)acetic acid, a salt thereof, a solvate thereof,
wherein the allergic disease is allergic rhinitis, allergic conjunctivitis, or bronchial asthma.

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Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient

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Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient

Life of this patent

Abstract

Claims2