Modulation of apolipoprotein (A) expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsRosanne M. Crooke, Mark J. Graham
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Abstract
Compounds, compositions and methods are provided for modulating the expression of apolipoprotein(a). The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein(a). Methods of using these compounds for modulation of apolipoprotein(a) expression and for diagnosis and treatment of disease associated with expression of apolipoprotein(a) are provided.
Claims18
A compound comprising an antisense oligonucleotide 12 to 30 nucleobases in length targeting apolipoprotein(a), wherein said oligonucleotide comprises at least an 8-nucleobase portion of the nucleobase sequence of SEQ ID NO:
- 11.
A compound comprising an antisense oligonucleotide 20 nucleobases in length, wherein said oligonucleotide comprises at least an 8-nucleobase portion of the nucleobase sequence of SEQ ID NO:
- 11, wherein said oligonucleotide comprises a gap segment of ten linked 2′-deoxynucleotides which is flanked on each side by five 2′-O-methoxyethyl nucleotides, wherein each internucleoside linkage is a phosphorothioate linkage, and wherein each cytosine is a 5-methylcytosine.
Dependencies are inferred from the claim text.