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US 8,138,318 B2Granted
Hepatitis B pre-S2 nucleic acid
AssigneeAbbott Laboratories
InventorsPaul F. Coleman, Sandra K. Pearce
Life of this patent
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AssigneeAbbott Laboratories
InventorsPaul F. Coleman, Sandra K. Pearce
Estimating the term…
This invention relates to a nucleic acid molecule encoding a middle Hepatitis B virus (HBV) surface protein, a vector comprising the nucleic acid molecule, a host cell comprising the vector, and a composition comprising the expression products of this vector, which may comprise middle HBV surface protein, or a mixture of middle HBV surface protein and small HBV surface protein. The compositions of the invention may be useful for expressing a middle HBV surface protein, or a mixture of small and middle HBV surface proteins in defined ratios, determining the binding of an antibody to a middle or small HBV surface protein, determining the quality of an anti-middle or an anti-small HBV surface protein antibody, or determining the quality of a kit containing anti-middle or anti-small HBV surface protein antibodies.
An isolated nucleic acid molecule encoding a middle Hepatitis B virus surface protein (MHB), wherein the nucleotide sequence of said molecule comprises a preS2 initiation sequence, wherein said preS2 initiation sequence starts with AAG or GAG nucleic acid sequence from the 5′ end and before the initiation codon ATG of the preS2.
A composition comprising isolated, recombinant MHB at a concentration of 1×10−12 to 1×10−2 gms.
Dependencies are inferred from the claim text.