Anti-alpha V immunoliposome compositions, methods and uses

An antibody derived targeting-ligand capable of monovalent binding and having specificity for alpha V integrin comprising:

• (a) a first polypeptide domain comprising the light chain variable region comprising residues 1-108 of SEQ ID NO:
• 2;
• (b) a second polypeptide domain comprising the heavy chain variable region comprising residues 1-119 of SEQ ID NO:
• 1, wherein the heavy chain variable region has a leucine substitution at the 18th amino acid;
• (c) further comprising at least one peptide linker linking said first and second polypeptide domains into a single chain Fv polypeptide wherein the linker has an amino acid sequence of the formula (Gly4Ser)n of SEQ ID NOS:
• 6-9 where n is an integer of 1-4:
• and wherein the targeting ligand retains specificity for at least one alpha V integrin.