Compositions and methods of monoclonal and polyclonal antibodies specific for T cell subpopulations
AssigneesBeth Israel Deaconess Medical Center, Inc., Dana-Farber Cancer Institute, Inc., The General Hospital Corporation
InventorsMark A. Exley, Samuel B. Wilson, Steven P. Balk
Life of this patent
Estimating the term…
Abstract
The invention provides compounds and methods for the ex vivo or in vivo expansion of NK T cells, CD1d-reactive T cells, and JαQ+ T cells, and the modulation of their activities. These compounds and methods have diagnostic and therapeutic applications.
Claims13
A purified antibody, or a fragment or derivative thereof, that binds to the human CDR3 loop of a T cell receptor (TCR) α chain present on an invariant NKT cell, but does not substantially recognize and bind to other molecules in a biological sample which naturally includes other proteins or cells.
Dependencies are inferred from the claim text.