Modified proteins, designer toxins, and methods of making thereof
AssigneeResearch Development Foundation
InventorsMichael G. Rosenblum, Lawrence Cheung
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Abstract
The present invention concerns methods of reducing the antigenicity of a proteinaceous compound while maintaining the compounds biological activity, as well as proteinaceous compositions with biological activity but reduced antigenicity. These methods and compositions have significant benefits to a subject in need of such compounds and compositions. Also included are modified toxin compounds that are truncated and/or possess reduce antigenicity. Such designer toxins have therapeutic, diagnostic, and preventative benefits, particularly as immunotoxins. Methods of treating cancer using these immunotoxins are provided.
Claims16
An immunotoxin comprising a recombinant gelonin toxin and a ligand that specifically targets a receptor expressed on a target cell, wherein the recombinant gelonin toxin is modified relative to full-length, wild-type gelonin through the removal of one or more sequence regions that are antigenic in humans.
Dependencies are inferred from the claim text.