High water content ophthalmic devices
AssigneeBausch & Lomb Incorporated
InventorsRichard I. Blackwell, Joseph C. Salamone, Jay F. Kunzler
Life of this patent
Estimating the term…
Abstract
An ophthalmic device is disclosed that is a polymerization product of a monomeric mixture comprising (a) a major amount of a non-silicone-containing hydrophilic monomer; (b) a hydrophobic monomer; and (c) a crosslinking agent, wherein the ophthalmic device has an equilibrium water content of at least about 70 weight percent and further wherein the ophthalmic device has an evaporative dehydration barrier layer on the surface thereof. A method for the mitigation of evaporative corneal dehydration employing the high water content ophthalmic device is also disclosed.
Claims25
An ophthalmic device that is a polymerization product of a monomeric mixture comprising:
- (a) a major amount of a non-silicone-containing hydrophilic monomer;
- (b) a hydrophobic monomer;
- and (c) a crosslinking agent, wherein the ophthalmic device has an equilibrium water content of at least about 70 weight percent and further wherein the ophthalmic device has an evaporative dehydration barrier layer on the surface thereof.
An ophthalmic device that is a polymerization product of a monomeric mixture comprising:
- (a) a major amount of a non-silicone-containing hydrophilic monomer;
- (b) a hydrophobic monomer;
- and (c) a crosslinking agent, wherein the ophthalmic device has an equilibrium water content of at least about 70 weight percent and further wherein the ophthalmic device has a dehydration rate of less than or equal to about 0.600 mg/minute.
A method comprising the step of casting a monomeric mixture comprising (a) a major amount of a non-silicone-containing hydrophilic monomer;
- (b) a hydrophobic monomer;
- and (c) a crosslinking agent in a hydrophobic substrate to form an ophthalmic device having an evaporative dehydration barrier layer on the surface thereof and wherein the ophthalmic device has an equilibrium water content of at least about 70 weight percent.
A method for substantially mitigating evaporative corneal dehydration associated with an ophthalmic device having an equilibrium water content of at least about 70 weight percent, the method comprising contacting the surface of an eye of a subject with an ophthalmic device that is a polymerization product of a monomeric mixture comprising:
- (a) a major amount of a non-silicone-containing hydrophilic monomer;
- (b) a hydrophobic monomer;
- and (c) a crosslinking agent, wherein the ophthalmic device has an equilibrium water content of at least about 70 weight percent and further wherein the ophthalmic device has a dehydration rate of less than or equal to about 0.600 mg/minute.
Dependencies are inferred from the claim text.