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US 8,138,218 B2Granted
Growth hormone secretagogues
AssigneeIpsen Pharma S.A.S.
InventorsZheng Xin Dong, John S. Eynon, Yeelana Shen
Life of this patent
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Abstract
A family of peptides and peptidomimetic compounds useful as GHS analogs according to either formula (I) or (II) as depicted below: or a pharmaceutically acceptable salts thereof, wherein the variables are as defined in the specification.
Claims50
A compound of the formula (I)
- wherein
- X is
- Y is H or NR12R13;
- Z is —C(O)— or —SO2—;
- n is, independently for each occurrence. 1, 2, 3, 4, 5, 6, 7, or 8;
- R1 and R3 each is, independently, H or (C1-C4)alkyl;
- R2 and R4 each is, independently,
- R5 is H, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, substituted (C1-C6)alkyl, substituted (C2-C6)alkenyl, substituted (C2-C6)alkynyl, aryl, alkylaryl, alkylarylalkyl or arylalkylaryl;
- R8 and R9 each is, independently, (C1-C6)alkyl or substituted (C1-C6)alkyl;
- R6, R7, R10, R11, R12 and R13 each is, independently, H, (C1-C6)alkyl or substituted (C1-C6)alkyl;
- and
- Q is H or (C1-C4)alkyl;
- provided that:
- at least one of R2 and R4 is
- in said compound;
- or a pharmaceutically acceptable salt thereof.
13 more elements
Dependencies are inferred from the claim text.