Substituted indanyl sulfonamide compounds, their preparation and use as medicaments

A substituted indanyl sulfonamide compound of general formula I,

• wherein
• R1, R2, R3, R4, K independent from one another, each represent an hydrogen atom;
• or a linear or branched, saturated or unsaturated C1-5 aliphatic radical which may be substituted with 1, 2 or 3 substituent(s) independently selected from the group consisting of F, Cl, Br, —OH, —NH2, —SH, —O—CH3, —O—C2H5, —NO2, —CN, —NH—CH3 and —S—CH3;
• R5, R6, R7 and R8, independent from one another, each represent a hydrogen atom;
• —NO2;
• —NH2;
• —SH;
• —OH;
• —CN;
• —C(═O)—H;
• —C(═O)—R10;
• —OR11;
• —SR12;
• —S(═O)2—N(R14)R15;
• —N(R16)—S(═O)2—R17;
• —NH—R18;
• —NR19R20;
• F;
• Cl, Br;
• I;
• a linear or branched, saturated or unsaturated C1-6 aliphatic radical which may be substituted with 1, 2 or 3 substituent(s) independently selected from the group consisting of F, Cl, Br, —OH, —NH2, —SH, —O—CH3, —O—C2H5, —NO2, —CN, —NH—CH3 and —S—CH3;
• or a 5- to 14-membered aryl or heteroaryl radical, which may be substituted with 1, 2 or 3 substituent(s) independently selected from the group consisting of —CF3, C1-5-alkyl, —O—C1-5-alkyl, —S—C1-5-alkyl, —C(═O)—OH, —C(═O)—O—C1-5-alkyl, —O—C(═O)—C1-5-alkyl, F, Cl, Br, I, —CN, —OCF3, —SCF3, —OH, —SH, —NH2, —NH(C1-5-alkyl), —N(C1-5-alkyl)2, —NH—C(═O)—C1-5-alkyl, —N(C1-5-alkyl)-C(═O)—C1-5-alkyl, —NO2, —CHO, —CF2H, —CFH2, —C(═O)—NH2, —C(═O)—NH(C1-5-alkyl), —C(═O)—N(C1-5-alkyl)2, —S(═O)2—C1-5-alkyl, —S(═O)2-phenyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, phenoxy and benzyl and which may be bonded via a linear or branched C1-6 alkylene group and wherein the heteroaryl radical contains 1, 2 or 3 heteroatom(s) independently selected from the group consisting of nitrogen, oxygen and sulfur as ring member(s);
• with the condition that at least one of the substituents R5, R6, R7 and R8 represents a —S(═O)2—N(R14)R15 or a —N(R16)—S(═O)2—R17 radical;
• A represents
• which means (Ib) type compounds:
• wherein
• X represents NH, O or S
• R23 represents NH2 or NH—NH2
• R10 to R12 and R14 to R20, independent from one another, each represent a hydrogen atom;
• a linear or branched, saturated or unsaturated C1-5 aliphatic radical which may be substituted with 1, 2 or 3 substituent(s) independently selected from the group consisting of F, Cl, Br, —OH, —NH2, —SH, —O—CH3, —O—C2H5, —NO2, —CN, —NH—CH3 and —S—CH3;
• a saturated or unsaturated 3 to 8-membered cycloaliphatic radical, which may be substituted with 1, 2 or 3 substituent(s) independently selected from the group consisting of C1-5-alkyl, —O—C1-5-alkyl, oxo (═O), thioxo (═S), —C(═O)—OH, —C(═O)—O—C1-5-alkyl, —O—C(═O)—C1-5-alkyl, F, Cl, Br, I, —CN, —CF3, —OCF3, —SCF3, —OH, —SH, —NH2, —NH(C1-5-alkyl), —N(C1-5-alkyl)2, —NO2, —CHO, —CF2H, —CFH2, —C(═O)—NH2, —C(═O)—NH(C1-5-alkyl), —C(═O)—N(C1-5-alkyl)2, —S(═O)2—C1-5-alkyl, —S(═O)2-phenyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, phenoxy and benzyl and which may optionally contain 1, 2 or 3 heteroatom(s) independently selected from the group consisting of nitrogen, oxygen and sulfur as ring member(s) and which may be bonded via a linear or branched C1-6 alkylene group;
• or a 5- to 14-membered aryl or heteroaryl radical, which may be substituted with 1, 2 or 3 substituent(s) independently selected from the group consisting of —CF3, C1-5-alkyl, —O—C1-5-alkyl, —S—C1-5-alkyl, —C(═O)—OH, —C(═O)—O—C1-5-alkyl, —O—C(═O)—C1-5-alkyl, F, Cl, Br, I, —CN, —OCF3, —SCF3, —OH, —SH, —NH2, —NH(C1-5-alkyl), —N(C1-5-alkyl)2, —NH—C(═O)—C1-5-alkyl, —N(C1-5-alkyl)-C(═O)—C1-5-alkyl, —NO2, —CHO, —CF2H, —CFH2, —C(═O)—NH2, —C(═O)—NH(C1-5-alkyl), —C(═O)—N(C1-5-alkyl)2, —S(═O)2—C1-5-alkyl, —S(═O)2-phenyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, phenoxy and benzyl and which may be bonded via a linear or branched C1-6 alkylene, C2-6 alkenylene or C2-6 alkinylene group and wherein the heteroaryl radical contains 1, 2 or 3 heteroatom(s) independently selected from the group consisting of nitrogen, oxygen and sulfur as ring member(s);
• or a pharmaceutically acceptable salt thereof optionally in form of one of its stereoisomers, a racemate or in form of a mixture of at least two of its stereoisomers, in any mixing ratio, or a physiologically acceptable salt thereof.