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US 8,138,207 B2Granted
Aminocarbonyl-substituted 8-N-benzimidazoles, methods for their preparation and their use in pharmaceutical compositions
AssigneeSanofi-Aventis
InventorsElisabeth DeFossa, Karl Schoenafinger, Gerhard Jaehne, Christian Buning, Georg Tschank, Ulrich Werner
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Abstract
The present invention comprises the use of amino-carbonyl-substituted 8-N-benzimidazoles compounds of formula I wherein R3, R4-R5, R11 and R20-R21 are hereinafter defined which display a therapeutically utilizable blood sugar-lowering action. These compounds are intended to be particularly suitable in the treatment of diabetes, carbohydrate and lipid metabolic disorders and other blood sugar complications.
Claims2
The compound of formula I
- wherein
- R20 is H;
- R21 is selected from the group consisting of (C6-C10)-aryl and (C1-C6)-alkylene-(C6-C10)-aryl, where the aryl radicals may be mono- or polysubstituted by F, Cl, Br, I, CN, NO2, SH, OH, CF3, (C1-C6)-alkyl, O—(C1-C6)-alkyl, or S—(C1-C6)-alkyl;
- R3 is (C2-C10)-alkenyl;
- R4, R5 are each H;
- R11 is selected from the group consisting of F, Cl, Br, I, (C1-C6)-alkyl, (C3-C8)-cycloalkyl, NH2, NH(C1-C6)-alkyl, NH(C3-C7)-cycloalkyl, N((C1-C6)-alkyl)2 and O—(C1-C6)-alkyl, where the alkyl groups may be mono- or polysubstituted by F, Cl, Br or I;
- and
- n is 0;
- or a pharmaceutically acceptable salt thereof.
6 more elements
Dependencies are inferred from the claim text.