Heteroarylalkoxy-substituted quinolone inhibitors of PDE4
AssigneeKalypsys, Inc.
InventorsSteven P. Govek, Clay Beauregard, Daniel A. Gamache, Mark R. Hellberg, Stewart A. Noble, Andrew K. Shiau, David J. Thomas, John M. Yanni
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Abstract
The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
Claims19
A compound of structural Formula VI
- or a salt thereof, wherein:
- R1 is —(CH2)sG1G2G3;
- R2 is methyl;
- s is 6;
- G1 is null;
- G2 is heterocycloalkyl, which may be optionally substituted;
- G3 is null;
- and
- R20 and R24 are halogen.
A compound selected from the group consisting of:
- 4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(6-(4-methylpiperazin-1-yl) hexyloxy)quinolin-2(1H)-one,
- 4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(6-morpholinohexyloxy)quinolin-2(1H) -one,
- 4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(6-(piperazin-1-yl)hexyloxy)quinolin -2(1H)-one,
- 4-(3,5-dichloropyridin-4-ylamino)-8-(6-(4-ethylpiperazin- 1-yl)hexyloxy)-7-methoxyquinolin -2(1H)-one,
- 8-(6-(1,4-Diazepan-1-yl)hexyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxyquinolin-2(1H)-one
- 4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(6-(4-methyl-1,4-diazepan-1-yl)hexyloxy)quinolin-2(1H)-one,
- 8-(6-(2H-tetrazol-5-yl)hexyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxyquinolin-2(1H)-one,
- 8-(6-(1H-imidazol-1-yl)hexyloxy)-4-(3,5-dimethylpyridin-4-ylamino)-7-methoxyquinolin-2(1H)-one, and
- 8-(6-(2H-tetrazol-5-yl)hexyloxy)-4-(3,5-dimethylpyridin-4-ylamino)-7-methoxyquinolin-2(1H)-one.
4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(6-(4-methylpiperazin-l-yl)hexyloxy)quinolin-2(1H)-one, or a salt thereof.
4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(6-morpholinohexyloxy)quinolin-2(1H)-one, or a salt thereof.
Dependencies are inferred from the claim text.