Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase

A compound of formula (I),

• the N-oxide forms, the pharmaceutically acceptable addition salts and the stereo-chemically isomeric forms thereof, wherein
• X is N;
• Y is independently CH or CH2 and when Y is CH then a substituent of CH is attached to the Y atom of the ring structure;
• n is 0 or 1 and when n is 0 than a direct bond is intended;
• R1 is phenyl, or naphtalenyl;
• wherein
• each of said phenyl or naphtalenyl is optionally substituted with one or two substituents each independently selected from halo, C1-6alkyl, C1-6alkyloxy, polyhaloC1-6alkyl, aryl, hydroxy, cyano, amino, C1-6alkylcarbonylamino,
• C1-6alkylsulfonylamino, hydroxycarbonyl, C1-6alkyloxycarbonyl, hydroxyC1-6alkyl, C1-6alkyloxymethyl, aminomethyl, C1-6alkylaminomethyl,
• C1-6alkylcarbonylaminomethyl, C1-6alkylsulfonylaminomethyl, aminosulfonyl, C1-6alkylaminosulfonyl or heterocyclyl;
• R2 is —CH2—R5, trifluoromethyl, —C(═O)—R6, or —CH2—NR7R8;
• wherein
• each R5 is independently selected from hydrogen, hydroxy, C1-6alkyloxy, piperazinyl, N-methylpiperazinyl, morpholinyl, thiomorpholinyl, imidazolyl or triazolyl;
• each R6 is independently selected from hydroxy, C1-6alkyloxy, amino or mono- or di(C1-6alkyl)amino, C3-6cycloalkylamino, piperazinyl, N-methylpiperazinyl, morpholinyl or thiomorpholinyl;
• each R7 and R8 are independently selected from hydrogen, C1-6alkyl, C1-6alkylcarbonyl, C1-6alkylsulfonyl, or mono-or di(C1-4alkyl)aminosulfonyl;
• R3 is hydrogen, C1-6alkyl , cyanoC1-4alkyl, C1-6alkyloxycarbonyl, hydroxyC1-6alkyl, C1-6alkyloxyC1-6alkyl, C3-6cycloalkyl, C3-6cycloalkylC1-6alkyl, arylC1-6alkyl, C1-6alkylcarbonyl, C1-6alkylsulfonyl;
• R4 is hydroxy.