Injectable meclizine formulations and methods
AssigneeGenebiology, Inc.
InventorsWalker Anderson Long, Edwin Curran Murphy, III
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Abstract
Methods of treating or preventing a vertigo, nausea, or vomiting condition comprising injecting a subject with a pharmaceutically acceptable formulation consisting essentially of an effective amount of meclizine or a pharmaceutically acceptable salt thereof, a chemically modified cyclodextrin, and an aqueous carrier medium having a pH between about 2 and about 7 are disclosed. An injectable pharmaceutical formulation for treating or preventing a vertigo, nausea, or vomiting condition consisting essentially of an effective amount of meclizine, a chemically modified cyclodextrin, and an aqueous carrier medium having a pH between about 2 and about 7 is also disclosed.
Claims33
A method of treating a vertigo condition, the method comprising:
- providing a pharmaceutically acceptable formulation consisting essentially of:
- a therapeutically effective amount of meclizine;
- a molar excess of at least one cyclodextrin selected from the group consisting of 2-hydroxypropyl-β-cyclodextrin and sulfobutyl ether-β-cyclodextrin;
- an aqueous carrier medium, the aqueous carrier medium having a pH between about 3 to about 7;
- and
- optionally a pharmaceutically acceptable preservative, a pharmaceutically acceptable antioxidant, a pharmaceutically acceptable osmolality adjusting agent, or combination thereof;
- and
- injecting the pharmaceutically acceptable formulation in a subject in need thereof.
A method of treating or preventing a nausea or vomiting condition, the method comprising:
- providing a pharmaceutically acceptable formulation consisting essentially of:
- a therapeutically effective amount of meclizine;
- a molar excess of at least one cyclodextrin selected from the group consisting of 2-hydroxypropyl-β-cyclodextrin and sulfobutyl ether-β-cyclodextrin;
- an aqueous carrier medium, the aqueous carrier medium having a pH between about 3 to about 7;
- and
- optionally a pharmaceutically acceptable preservative, a pharmaceutically acceptable antioxidant, a pharmaceutically acceptable osmolality adjusting agent, or combination thereof;
- and
- injecting the pharmaceutically acceptable formulation in a subject in need thereof.
Dependencies are inferred from the claim text.