Pyrazole derivatives as sigma receptors antagonists

Compounds of formula (I),

• wherein
• R1 represents a hydrogen atom;
• F;
• Cl;
• Br;
• I;
• CF3;
• OH;
• SH;
• NH2;
• CN;
• an unbranched or branched, saturated or unsaturated, substituted or unsubstituted C1-6 aliphatic group;
• an unbranched or branched, saturated or unsaturated, substituted or unsubstituted alkoxy radical;
• a saturated or unsaturated, substituted or unsubstituted, optionally at least one heteroatom as ring member containing cycloalkyl group, which may be condensed with a substituted or unsubstituted mono- or polycyclic ring system;
• a branched or unbranched, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group in which the cycloalkyl group is substituted or unsubstituted;
• a substituted or unsubstituted aryl group which may be condensed with a substituted or unsubstituted mono- or polycyclic ring system;
• a substituted or unsubstituted heteroaryl group which may be condensed with a substituted or unsubstituted mono- or polycyclic ring system;
• a branched or unbranched alkyl-aryl group in which the aryl group is substituted or unsubstituted and/or condensed with a mono- or polycyclic ring system;
• a branched or unbranched alkyl-heteroaryl group in which the heteroaryl group is substituted or unsubstituted and/or condensed with a mono- or polycyclic ring system;
• a (C═O)—R7 group;
• a (C═O)—O—R8 group;
• a (S═O2)—R9 group;
• or a (C═O)—NR10R11 group;
• R2 represents a hydrogen atom;
• F;
• Cl;
• Br;
• I;
• CF3;
• OH;
• SH;
• NH2;
• CN;
• an unbranched or branched, saturated or unsaturated, substituted or unsubstituted aliphatic group;
• an unbranched or branched, saturated or unsaturated, substituted or unsubstituted alkoxy radical;
• a saturated or unsaturated, substituted or unsubstituted, optionally at least one heteroatom as ring member containing cycloalkyl group, which may be condensed with a substituted or unsubstituted mono- or polycyclic ring system;
• a branched or unbranched, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group in which the cycloalkyl group is substituted or unsubstituted;
• a substituted or unsubstituted aryl group which may be condensed with a substituted or unsubstituted mono- or polycyclic ring system;
• a substituted or unsubstituted heteroaryl group which may be condensed with a substituted or unsubstituted mono- or polycyclic ring system;
• a branched or unbranched alkyl-aryl group in which the aryl group is substituted or unsubstituted and/or condensed with a mono- or polycyclic ring system;
• a branched or unbranched alkyl-heteroaryl group in which the heteroaryl group is substituted or unsubstituted and/or condensed with a mono- or polycyclic ring system;
• a (C═O)—R7 group;
• a (C═O)—O—R8 group;
• a (S═O)—R9 group;
• or a (C═O)—NR10R11 group;
• R3 is hydrogen;
• R4 and R5 form together with the bridging nitrogen atom a substituted or unsubstituted heterocyclyl group which is optionally condensed with a substituted or unsubstituted mono- or polycyclic ring system;
• X represents an oxygen atom;
• a CH—R12 group with R12 being a —CH3, SH, OH, NH2, CF3 group;
• Cl, F, Br, I, or CN;
• Y represents a (S═O2) group;
• m is selected from 1, 2, 3 or 4;
• n is selected from 0 or 1;
• p is selected from 0 or 1;
• s is selected from 1, 2, 3 or 4;
• and n plus p is 1;
• R7, R8, R9, R10 and R11, identical or different, represent a hydrogen atom;
• an unbranched or branched, saturated or unsaturated, substituted or unsubstituted C1-6 aliphatic group;
• a branched or unbranched, substituted or unsubstituted C1-6 alkoxy radical;
• a saturated or unsaturated, substituted or unsubstituted, optionally at least one heteroatom as ring member containing cycloalkyl group;
• a branched or unbranched, substituted or unsubstituted, optionally at least one heteroatom as ring member containing C1-6 alkyl-cycloalkyl group;
• a substituted or unsubstituted aryl group;
• a substituted or unsubstituted heteroaryl group;
• a branched or unbranched, substituted or unsubstituted C1-6 alkyl-aryl;
• a branched or unbranched, substituted or unsubstituted C1-6 alkyl-heteroaryl group;
• optionally in form of one of the stereoisomers, a racemate or in form of a mixture of at least two of the stereoisomers, in any mixing ratio, or a corresponding salt thereof.