Isoxazole derivatives and pharmaceutical compositions comprising the same
AssigneeKaohsiung Medical University
InventorsCherng-Chyi Tzeng, Yeh-Long Chen, Gwo-Jaw Wang, Mei-Ling Ho, Je-Ken Chang, Yin-Chih Fu
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Abstract
An isoxazole derivative is provided. The isoxazole derivative has following formula: wherein R1, R2, R3, R4 and R5, independently, include hydrogen, hydroxy or C1-C12 alkoxy optionally substituted with oxirane, thiirane, aziridine, amino, cycloamino, aminohydroxy or cycloaminohydroxy. The invention also provides a pharmaceutical composition for treatment of osteoporosis and cancer including an isoxazole derivative or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
Claims4
An isoxazole derivative having the following formula:
- wherein
- R1, R2, R3, and R4, independently, consist of hydrogen, hydroxy or C1-C12 alkoxy optionally substituted with oxirane, thiirane, aziridine, amino, cycloamino, aminohydroxy or cycloaminohydroxy;
- and
- R5 consists of C1-C12 alkoxy optionally substituted with oxirane, thiirane, aziridine, amino, cycloamino, aminohydroxy or cycloaminohydroxy.
Dependencies are inferred from the claim text.