Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors

A compound of general Formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• A is —Z—(CH2)p-(hetCyc2a), —Z-(hetCyc2b), Z—R10 or Z—R11;
• Z is O or NH;
• p is 0, 1, or 2;
• hetCyc2a is a 5 or 6 membered heterocyclic ring optionally substituted with one or more R9 groups;
• hetCyc2b is a 7-12 membered spirocyclic or bridged heterobicyclic ring system optionally substituted with one or more R9 groups;
• R10 is (1-6C)alkyl substituted with NR′R″;
• R11 is (5-6C)cycloalkyl substituted with NR′R″;
• B is H, CN, ORh, Ar1, hetAr2, C(O)NRiRj, C(O)-hetCyc3, C(O)NH(1-6C alkyl)-hetCyc3, C(O)(1-6C alkyl)-hetCyc3, SRk, SO2N(1-6C alkyl)2, (1-6C alkyl)NR′R″ or (1-3C)alkyl;
• R1, R2, R3 and R4 are independently H, F, Cl, CN, Me, Et, isopropyl, cyclopropyl, C(O)NR′R″, CH2OH, or hetAr3;
• R1a is H, F, Cl, or Me;
• R5, R6, R7 and R8 are independently H, F, Cl, CN or Me;
• each R9 is independently selected from halogen, CN, CF3, (1-6C)alkyl, NRaRb, -(1-6C alkyl)NRaRc, ORa, (1-6C alkyl)ORa [optionally substituted with amino], C(O)NRaRc, C(O)(CRxRy)NRaRc, NHC(O)Re, NHC(O)(CRmRn)NRaRc, NHC(O)NRfRg, (1-6C alkyl)-hetAr1, (1-6C alkyl)-hetCyc1, oxo, and C(O)O(1-6C alkyl);
• each Ra is independently H or (1-6C)alkyl;
• each Rb is independently H, (1-6C)alkyl, (1-6C alkyl)OH, (3-6C)cycloalkyl, CH2hetAr4, (1-6C fluoroalkyl) or -(1-6C alkyl)-O-(1-6C alkyl),
• each Rc is independently H, (1-6C)alkyl, (3-6C)cycloalkyl, or aryl;
• each Re is independently (1-6C alkyl);
• each Rf and Rg is independently H or (1-6C alkyl);
• Rh is H, CF3, (1-6C)alkyl, (1-6Calkyl)-(3-6C cycloalkyl), (1-6C alkyl)-O-(1-6C alkyl), (1-6C alkyl)OH, (1-6C alkyl)-S-(1-6C alkyl), (1-6C alkyl)NR′R″, hetCyc4,(1-6C alkyl)hetCyc4, (1-6C alkyl)aryl, or (1-6C alkyl)-hetAr5;
• Ri is H or 1-6C alkyl;
• Rj is (1-6C)alkyl, (1-6C alkyl)-O-(1-6C alkyl), or (1-6C alkyl)-OH;
• Rk is (1-6C)alkyl, (3-6C)cycloalkyl, or (1-6C alkyl)-O-(1-6C alkyl);
• Rm and Rn are independently H or (1-6C alkyl);
• Rx and Ry are independently H or (1-6C alkyl),
• or Rx and Ry together with the atom to which they are attached form a cyclopropyl ring;
• Ar1 is aryl optionally substituted with OH, O-(1-6C alkyl), C(O)2(1-6C alkyl), or (1-6C alkyl)NR′R″;
• hetCyc1 is a 5-6 membered heterocyclic ring which is optionally substituted with (1-6C)alkyl or OH;
• hetCyc3 and hetCyc4 are independently a 5 or 6 membered heterocyclic ring optionally substituted with OH or —O(1-6C alkyl);
• hetAr1 and hetAr2 are a 5-6 membered heteroaryl ring optionally substituted with one to three groups independently selected from (1-6C)alkyl, (3-6C)cycloalkyl, halogen, CN, CF3, OCH2F, OCF3, O(1-6C alkyl), O(3-6C)cycloalkyl, and NR′R″;
• hetAr3 and hetAr4 are independently a 5-6 membered heteroaryl ring;
• hetAr5 is a 5-6 membered heteroaryl ring optionally substituted with (1-6C)alkyl;
• and
• R′ and R″ are independently H or (1-6C)alkyl.