Composition for inhibiting function of human Flt3
AssigneeTakara Bio Inc.
InventorsMasazumi Yasumoto, Masamitsu Shimada, Fumitsugu Hino, Ikunoshin Kato
Life of this patent
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Abstract
To provide a means of controlling the function of Flt3. A composition for inhibiting the function of human Flt3, a method of inducing apoptosis by using the composition, and a kit for the method.
Claims8
A composition comprising a nucleic acid of which target is at least one region selected from the group consisting of a juxtamembrane region, a kinase region and an ATP-binding site region in human Flt3 and which can inhibit the function of Flt3, wherein said composition comprises a nucleic acid selected from the group consisting of:
- a nucleic acid wherein a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 2 and a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 3 are combined,
- a nucleic acid wherein a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 5 and a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 6 are combined,
- a nucleic acid wherein a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 8 and a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 9 are combined,
- a nucleic acid wherein a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 33 and a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 34 are combined,
- a nucleic acid wherein a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 36 and a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 37 are combined, and
- a nucleic acid wherein a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 39 and a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 40 are combined.
A composition comprising a vector carrying a nucleic acid of which target is at least one region selected from the group consisting of a juxtamembrane region, a kinase region and an ATP-binding site region in human Flt3 and which can inhibit the function of Flt3, wherein said composition comprises a nucleic acid selected from the group consisting of:
- a nucleic acid wherein a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 2 and a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 3 are combined,
- a nucleic acid wherein a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 5 and a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 6 are combined,
- a nucleic acid wherein a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 8 and a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 9 are combined,
- a nucleic acid wherein a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 33 and a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 34 are combined,
- a nucleic acid wherein a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 36 and a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 37 are combined, and
- a nucleic acid, wherein a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 39 and a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 40 are combined.
Dependencies are inferred from the claim text.