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US 8,138,158 B2Granted
Compositions and methods for therapy for diseases characterized by defective chloride transport
AssigneeChildren's Hospital & Research Center at Oakland
InventorsHorst Fischer, Beate Illek
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Abstract
Compositions and methods for therapy of cystic fibrosis, asthma, and other conditions characterized by defective chloride transport are provided. The compositions comprise one or more compounds such as flavones and/or isoflavones, ascorbate and/or derivatives thereof capable of stimulating chloride transport in epithelial tissues. Therapeutic methods involve the administration (e.g., orally or via inhalation) of such compositions to a patient afflicted with cystic fibrosis, asthma, and/or another condition responsive to stimulation of chloride transport.
Claims3
A composition comprising:
- (a) one or more flavones or isoflavones capable of stimulating chloride secretion;
- (b) one or more of:
- (i) a compound that increases expression of a CFTR protein in an epithelial cell;
- and
- (ii) a chemical chaperone that increases trafficking of a CFTR protein to a plasma membrane in an epithelial cell;
- (c) one or more of a compound selected from the group consisting of ascorbic acid, ascorbate salts, dehydroascorbic acid and resveratrol;
- and
- (d) a physiologically acceptable carrier.
5 more elements
Dependencies are inferred from the claim text.