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AssigneeBrown University Research Foundation
InventorsJustin R. Fallon, Beth McKechnie, Michael Rafii, Hilliary Creely, Mark A. Bowe, Alison Amenta, Mary Lynn Mercado, Hiroki Hagiwara
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The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Example of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders.
A method for treating amyotrophic lateral sclerosis, denervation atrophy, cachexia, spinal muscular atrophy, or disuse atrophy in a subject, comprising administering to the subject a pharmaceutically effective amount of a polypeptide that comprises a sequence at least 90% identical to amino acids 38-368 of SEQ ID NO:
Dependencies are inferred from the claim text.