GDNF derived peptides
AssigneeCopenhagen University
InventorsElisabeth Bock, Vladimir Berezin
Life of this patent
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Abstract
The present invention relates to peptide fragments derived from the proteins belonging to the TGFbeta superfamily, pharmaceutical compositions comprising these peptide fragments and uses thereof for treatment of a disease or condition wherein the effects of stimulating neuronal cell differentiation, neuronal cell survival, stimulating neural plasticity associated with learning and memory and/or inhibiting inflammatory response are beneficial for treatment.
Claims52
A method of stimulating neurite outgrowth and/or increasing neuronal cell survival in a subject, comprising administering to said subject an effective amount of a compound which is a non-naturally occurring multimer comprising two or more peptides, which peptides may be the same or different, each peptide independently consisting of a sequence of 7 to 22 contiguous amino acid residues and comprising the formula (I):
- Xa-(x)-Xb-Xc-Xd-Xf
- wherein
- Xa is amino acid residue D, E or A,
- (x) is a sequence of two amino acid residues selected from V-S, K-I, L-S and L-G
- Xb, is amino acid residue F, L or W, and
- at least one of Xc, Xd or Xf is a charged or hydrophobic amino acid residue, with the proviso that Xf is not D or E,
- wherein said compound is not a homodimer consisting of two identical monomers in which the identical monomers are covalently linked by a disulfide bond,
- said compound being capable of stimulating neurite outgrowth or increasing neuronal cell survival.
A method of stimulating neurite outgrowth and/or increasing neuronal cell survival in a subject, comprising administering to said subject an effective amount of a compound which is a non-naturally occurring multimer comprising two or more peptides, which peptides may be the same or different, each independently consisting of a sequence of 7 to 22 contiguous amino acid residues and comprising the formula (I):
- Xa-(x)-XbXc-Xd-Xf
- wherein
- Xa is amino acid residue D, E or A,
- (x) is a sequence of two amino acid residues selected from V-S, K-I, L-S and L-G,
- Xb is amino acid residue F, L or W, and
- at least one of Xc, Xd or Xf is a charged or hydrophobic amino acid residue, with the proviso that Xf is not D or E,
- wherein said multimer comprises not more than 176 amino acid residues, not counting any dendrimeric lysine core,
- said compound being capable of stimulating neurite outgrowth or increasing neuronal cell survival.
A method of stimulating neurite outgrowth and/or increasing neuronal cell survival and/or binding to a GFRa receptor in a subject, comprising administering to said subject an effective amount of a compound which is a non-naturally occurring multimer comprising two or more peptides, which peptides may be the same or different, each peptide independently consisting of a sequence of 7 to 22 contiguous amino acid residues and comprising the formula (I):
- Xa-(x)-Xb-Xc-Xd-Xf
- wherein
- Xa is amino acid residue D, E or A,
- (x) is a sequence of two amino acid residues selected from V-S, K-I, L-S and L-G,
- Xb is amino acid residue F, L or W, and
- at least one of Xc, Xd or Xf is a charged or hydrophobic amino acid residue, with the proviso that Xf is not D or E,
- wherein said compound is not a homodimer consisting of two identical monomers in which the identical monomers are covalently linked by a disulfide bond,
- said compound being capable of stimulating neurite outgrowth or increasing neuronal cell survival or binding to a GFRa receptor.
Dependencies are inferred from the claim text.