Self-assembling peptide amphiphiles and related methods for growth factor delivery
AssigneeNorthwestern University
InventorsSamuel I. Stupp, Jack J. J. M. Donners, Gabriel A. Silva, Heather A. Behanna, Shawn G. Anthony
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Abstract
Amphiphilic peptide compounds comprising one or more epitope sequences for binding interaction with one or more corresponding growth factors, micellar assemblies of such compounds and related methods of use.
Claims14
A binding peptide consisting of an amino acid sequence selected from the group consisting of:
- YPVHPST (SEQ ID NO:7), KVPPANT (SEQ ID NO:9), KQALTQT (SEQ ID NO:10), WPALFTH (SEQ ID NO:11), PGPTVQG (SEQ ID NO:12), LHYPFMT (SEQ ID NO:13), QQTQAQH (SEQ ID NO:14), PIQPDER (SEQ ID NO:15), PFDPPVR (SEQ ID NO:16), DVSPAYH (SEQ ID NO:17), LPLGNSH (SEQ ID NO:8), LRNYSHS (SEQ ID NO:18), VYRHLPT (SEQ ID NO:19), RVSTWDT (SEQ ID NO:20), PAPRWIH (SEQ ID NO:21), RTTSPTA (SEQ ID NO:22), GKYPPTS (SEQ ID NO:23), AWKSVTA (SEQ ID NO:24), and LPSPIQK (SEQ ID NO:25).
A compound having the formula C15H31CO-VVVAAAKKK (SEQ ID NO:
- 3).
A compound selected from V3A3K3SG3LPLGNSH (SEQ ID NO:27) and V6K3SG3YPVHPST (SEQ ID NO:26).
A method of controlling the differentiation of stem cells into chondrocytes comprising contacting said stem cells with a composition comprising a micellar assembly comprising a peptide amphiphile having a hydrophobic component of an alkyl chain from six to twenty-two carbon atoms in length, a peptide component selected from YPVHPST (SEQ ID NO:7) and LPLGNSH (SEQ ID NO:8), and therebetween, a β-sheet forming unit selected from V3A3K3 (SEQ ID NO:3), V3A3E3 (SEQ ID NO:4), and V6K3.
Dependencies are inferred from the claim text.