Lipidomic approaches to determining drug response phenotypes in cardiovascular disease

A method of correlating a lipid profile with a positive or negative response to a statin treatment regimen, the method comprising:

• determining a lipid profile of a sample obtained from a mammalian subject before commencement of said treatment regimen;
• and
• correlating the lipid profile in the sample with a positive or negative response to said treatment regimen;
• wherein the positive response to treatment comprises one or more of a reduction in the level of total cholesterol, a reduction in the level of low density lipoprotein (LDL) cholesterol, a reduction in the level of high density lipoprotein (HDL) cholesterol and a reduction in the level of total triglyceride measured in a sample obtained following commencement of the treatment regimen as compared with the level prior to commencing said treatment regimen.

A method of correlating a lipid profile with a positive or negative response to a statin treatment regimen, the method comprising:

• determining a lipid profile of a sample obtained from a mammalian subject following commencement of the treatment regimen;
• and
• correlating the lipid profile in the sample with a positive or negative response to the treatment regimen;
• wherein the lipid profile evaluates 10 or more lipid metabolites within one or more lipid classes;
• and
• wherein the positive response to treatment comprises one or more of a reduction in the level of total cholesterol, a reduction in the level of low density lipoprotein (LDL) cholesterol, a reduction in the level of high density lipoprotein (HDL) cholesterol and a reduction in the level of total triglyceride detected in the sample obtained following commencement of the treatment regimen as compared with the level prior to commencing the treatment regimen.

A method of correlating a lipid profile with a positive or negative response to a statin treatment regimen, the method comprising:

• obtaining a lipid profile of a sample from a mammalian subject before commencement of said treatment regimen;
• and
• correlating the lipid profile in the sample with a positive or negative response to said treatment regimen;
• wherein the lipid profile evaluates 10 or more lipid metabolites within one or more lipid classes;
• and
• wherein the positive response to treatment comprises one or more of a reduction in the level of total cholesterol, a reduction in the level of low density lipoprotein (LDL) cholesterol, a reduction in the level of high density lipoprotein (HDL) cholesterol and a reduction in the level of total triglyceride detected in a sample obtained following commencement of the treatment regimen as compared with the level prior to commencing said treatment regimen.