Biocompatible, biodegradable polymer-based, lighter than or light as water scaffolds for tissue engineering and methods for preparation and use thereof
AssigneesDrexel University, The Wistar Institute, The Trustees of the University of Pennsylvania
InventorsCato T. Laurencin, Solomon R. Pollack, Elliot Levine, Edward Botchwey, Helen H. Lu, Mohammed Yusuf Khan
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Abstract
Scaffolds for tissue engineering prepared from biocompatible, biodegradable polymer-based, lighter than or light as water microcarriers and designed for cell culturing in vitro in a rotating bioreactor are provided. Methods for preparation and use of these scaffolds as tissue engineering devices are also provided.
Claims19
A scaffold for tissue engineering comprising a 3-dimensional network of microcarriers, said microcarriers comprising at least one biocompatible, biodegradable organic polymer and individually presenting an organic polymer surface to adjacent microcarriers and having densities less than or equal to that of water, wherein adjacent microcarriers are fused to one another at an interface, each interface comprising a region of direct polymer-polymer contact, and wherein the 3-dimensional network of microcarriers further comprises a network of interconnected pores.
Dependencies are inferred from the claim text.