Bovine adeno-associated viral (BAAV) vector and uses thereof
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsMichael Schmidt, Ioannis Bossis, John A. Chiorini
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Abstract
The present invention provides a bovine adeno-associated virus (BAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the BAAV vectors and particles.
Claims17
A vector system for producing infectious virus particles having a characteristic of BAAV, the system comprising:
- (a) a nucleotide sequence comprising SEQ ID NO:12;
- and,
- (b) at least one nucleic acid sequence selected from the group consisting of:
- (i) a nucleic acid sequence encoding a protein comprising an amino acid sequence selected from the group consisting of SEQ ID NO:7, SEQ ID NO:9, and SEQ ID NO:11;
- and,
- (ii) a nucleic acid sequence encoding a protein comprising an amino acid sequence selected from the group consisting of SEQ ID NO:3, and SEQ ID NO:5.
A vector system comprising:
- (a) a first vector comprising a nucleic acid sequence selected from the group consisting of:
- (i) a nucleic acid sequence encoding a capsid protein comprising an amino acid sequence selected from the group consisting of SEQ ID NO:7, SEQ ID NO:9, and SEQ ID NO:11;
- and,
- (ii) a nucleic acid sequence encoding a protein comprising an amino acid sequence selected from the group consisting of SEQ ID NO:3, and SEQ ID NO:5;
- and
- (b) a second vector comprising a nucleotide sequence comprising SEQ ID NO:12.
A vector system for producing infectious virus particles having a characteristic of BAAV, the system comprising one vector comprising (a) the nucleotide sequence of SEQ ID NO:12, and (b) a nucleic acid sequence encoding a protein selected from the group consisting of SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7, SEQ ID NO:9, and SEQ ID NO:11.
Dependencies are inferred from the claim text.