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US 8,137,941 B2Granted
Chondroitin polymerase and DNA encoding the same
AssigneeSeikagaku Corporation
InventorsToshio Ninomiya, Nobuo Sugiura, Koji Kimata
Life of this patent
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Abstract
A chondroitin polymerase having such properties that it transfers GlcUA and GalNAc alternately to a non-reduced terminal of a sugar chain from a GlcUA donor and a GalNAc donor, respectively, and the like; and a process for producing the chondroitin polymerase.
Claims14
A method for producing a sugar chain comprising:
- contacting an acceptor sugar chain with at least one GalNAc donor, GlcNAc donor, or GlcUA donor and an isolated protein that has chondroitin polymerase activity;
- wherein said isolated protein that has chondroitin polymerase activity comprises SEQ ID NO:
- 2, or an amino acid sequence identical to SEQ ID NO:
- 2 except that it has 1 to 30 of its amino acid residue(s) deleted, or substituted, or 1 to 30 amino acid residues inserted within the sequence of SEQ ID NO:
- 2;
- wherein said isolated protein is not membrane-bound.
3 more elements
Dependencies are inferred from the claim text.