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US 8,137,930 B2Granted
Attenuated Salmonella enterica serovar paratyphi A and uses thereof
AssigneeUniversity of Maryland, Baltimore
InventorsChristofer Vindurampulle, Eileen M. Barry, Myron M. Levine, James Galen
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Abstract
The present invention is drawn to a live, attenuated S. Paratyphi A strain, a live, attenuated S. Paratyphi A strain comprising a stabilized plasmid expression system, an S. Paratyphi conjugate vaccine, and methods of using these strains and conjugate vaccine.
Claims12
A method for preparing a conjugate vaccine, comprising:
- (a) mutating a strain of Salmonella Paratyphi A to generate an attenuated strain of Salmonella Paratyphi A,
- (b) isolating an O polysaccharide (OPS) and a flagellin protein from the attenuated strain of (a), wherein said flagellin protein is phase 1 flagellin (fliC), and
- (c) conjugating the OPS to the flagellin protein,
- thereby preparing a conjugate vaccine.
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Dependencies are inferred from the claim text.