Glycoprotein VI and uses thereof
AssigneeMillennium Pharmaceuticals, Inc.
InventorsSamantha J. Busfield, Jean-Luc Villeval
Life of this patent
Estimating the term…
Abstract
The invention provides isolated nucleic acid molecules and polypeptide molecules that encode glycoprotein VI, a platelet membrane glycoprotein that is involved platelet-collagen interactions. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
Claims11
A method of detecting a TANGO268 polypeptide, comprising the step of:
- contacting a sample with an antibody or antigen binding fragment thereof that binds to an amino acid sequence selected from the group consisting of SEQ ID NO:3, SEQ ID NO:16, and the amino acid sequence encoded by the cDNA insert of the plasmid deposited with ATCC as Accession Number 207180;
- wherein said antibody or binding fragment thereof specifically binds to an extracellular domain of said TANGO268 polypeptide.
Dependencies are inferred from the claim text.